Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace

Maja Adamska; Sophie Léger; Michael Brand; Thorsten Hadrys; Thomas Braun; Eva Bober

doi:10.1016/S0925-4773(00)00414-7

Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace

Maja Adamska, Sophie Léger, Michael Brand, Thorsten Hadrys, Thomas Braun, Eva Bober^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibulo-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo- acoustic ganglion. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Mechanisms of Development
Volume	97
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(00)00414-7
Publication status	Published - Oct 2000
Externally published	Yes

Access to Document

10.1016/S0925-4773(00)00414-7

Cite this

@article{0f9c5b74d0ea4229a145f2e6a917be73,

title = "Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace",

abstract = "An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibulo-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo- acoustic ganglion. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "FGF8, Homeobox, Inner ear, Lateral line, Nkx genes, Zebrafish",

author = "Maja Adamska and Sophie L{\'e}ger and Michael Brand and Thorsten Hadrys and Thomas Braun and Eva Bober",

year = "2000",

month = oct,

doi = "10.1016/S0925-4773(00)00414-7",

language = "English",

volume = "97",

pages = "161--165",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace

AU - Adamska, Maja

AU - Léger, Sophie

AU - Brand, Michael

AU - Hadrys, Thorsten

AU - Braun, Thomas

AU - Bober, Eva

PY - 2000/10

Y1 - 2000/10

N2 - An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibulo-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo- acoustic ganglion. (C) 2000 Elsevier Science Ireland Ltd.

AB - An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibulo-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo- acoustic ganglion. (C) 2000 Elsevier Science Ireland Ltd.

KW - FGF8

KW - Homeobox

KW - Inner ear

KW - Lateral line

KW - Nkx genes

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/0342844269

U2 - 10.1016/S0925-4773(00)00414-7

DO - 10.1016/S0925-4773(00)00414-7

M3 - Article

SN - 0925-4773

VL - 97

SP - 161

EP - 165

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1-2

ER -

Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace

Abstract

Access to Document

Other files and links

Fingerprint

Cite this