TY - JOUR
T1 - INOSITOL 1,4,5,-TRISPHOSPHATE PHOSPHATASE DEFICIENCY AND MALIGNANT HYPERPYREXIA IN SWINE
AU - Foster, P. S.
AU - Claudianos, C.
AU - Gesini, E.
AU - Hopkinson, K. C.
AU - Denborough, M. A.
PY - 1989/7/15
Y1 - 1989/7/15
N2 - The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5,-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.
AB - The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5,-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.
UR - http://www.scopus.com/inward/record.url?scp=0024348853&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(89)90182-7
DO - 10.1016/S0140-6736(89)90182-7
M3 - Article
SN - 0140-6736
VL - 334
SP - 124
EP - 127
JO - The Lancet
JF - The Lancet
IS - 8655
ER -