INOSITOL 1,4,5,-TRISPHOSPHATE PHOSPHATASE DEFICIENCY AND MALIGNANT HYPERPYREXIA IN SWINE

P. S. Foster; C. Claudianos; E. Gesini; K. C. Hopkinson; M. A. Denborough

doi:10.1016/S0140-6736(89)90182-7

INOSITOL 1,4,5,-TRISPHOSPHATE PHOSPHATASE DEFICIENCY AND MALIGNANT HYPERPYREXIA IN SWINE

P. S. Foster^*
, C. Claudianos
, E. Gesini
, K. C. Hopkinson
, M. A. Denborough

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5,-trisphosphate phosphatase (InsP₃5-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP₃5-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.

Original language	English
Pages (from-to)	124-127
Number of pages	4
Journal	The Lancet
Volume	334
Issue number	8655
DOIs	https://doi.org/10.1016/S0140-6736(89)90182-7
Publication status	Published - 15 Jul 1989

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title = "INOSITOL 1,4,5,-TRISPHOSPHATE PHOSPHATASE DEFICIENCY AND MALIGNANT HYPERPYREXIA IN SWINE",

abstract = "The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5,-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.",

author = "Foster, \{P. S.\} and C. Claudianos and E. Gesini and Hopkinson, \{K. C.\} and Denborough, \{M. A.\}",

year = "1989",

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doi = "10.1016/S0140-6736(89)90182-7",

language = "English",

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T1 - INOSITOL 1,4,5,-TRISPHOSPHATE PHOSPHATASE DEFICIENCY AND MALIGNANT HYPERPYREXIA IN SWINE

AU - Foster, P. S.

AU - Claudianos, C.

AU - Gesini, E.

AU - Hopkinson, K. C.

AU - Denborough, M. A.

PY - 1989/7/15

Y1 - 1989/7/15

N2 - The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5,-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.

AB - The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5,-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.

UR - https://www.scopus.com/pages/publications/0024348853

U2 - 10.1016/S0140-6736(89)90182-7

DO - 10.1016/S0140-6736(89)90182-7

M3 - Article

SN - 0140-6736

VL - 334

SP - 124

EP - 127

JO - The Lancet

JF - The Lancet

IS - 8655

ER -

INOSITOL 1,4,5,-TRISPHOSPHATE PHOSPHATASE DEFICIENCY AND MALIGNANT HYPERPYREXIA IN SWINE

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