Interaction of mononuclear nickel(II) enantiomers, Δ- And Λ-bis(1,10-phenanthroline) (dipyrido[3,2-a:2′,3′-c]phenazine) nickel(II) chloride, with calf thymus DNA

Hassan Hadadzadeh; Marzieh Daryanavard; Mahbod Morshedi

doi:10.1016/j.ica.2013.02.010

Interaction of mononuclear nickel(II) enantiomers, Δ- And Λ-bis(1,10-phenanthroline) (dipyrido[3,2-a:2′,3′-c]phenazine) nickel(II) chloride, with calf thymus DNA

Hassan Hadadzadeh^*, Marzieh Daryanavard, Mahbod Morshedi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Circular dichroism (CD) spectroscopy was used to investigate the interaction of Δ- and Λ-enantiomers of a mononuclear Ni(II) complex, [Ni(phen)₂(dppz)]²⁺ (where phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2′,3′-c]phenazine), with CT-DNA. The pure Ni(II) enantiomers were synthesized via a chiral precursor. The changes in the absorption and CD spectra upon binding provide detailed information about DNA binding of the enantiomers. The change in the CD spectra over time was used to calculate the racemization rates in the absence and presence of DNA. It was observed that the Δ-enantiomer racemizes slower than the Λ-enantiomer in the presence of DNA. Competition between the Ru(II) enantiomers, Δ- and Λ-[Ru(phen)₂(dppz)] ²⁺, and the Ni(II) enantiomers, Δ- and Λ-[Ni(phen) ₂(dppz)]²⁺, was also studied via luminescence titration.

Original language	English
Pages (from-to)	82-90
Number of pages	9
Journal	Inorganica Chimica Acta
Volume	400
DOIs	https://doi.org/10.1016/j.ica.2013.02.010
Publication status	Published - 1 May 2013

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@article{54689c17197f45588276a90e4425ea93,

title = "Interaction of mononuclear nickel(II) enantiomers, Δ- And Λ-bis(1,10-phenanthroline) (dipyrido[3,2-a:2′,3′-c]phenazine) nickel(II) chloride, with calf thymus DNA",

abstract = "Circular dichroism (CD) spectroscopy was used to investigate the interaction of Δ- and Λ-enantiomers of a mononuclear Ni(II) complex, [Ni(phen)2(dppz)]2+ (where phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2′,3′-c]phenazine), with CT-DNA. The pure Ni(II) enantiomers were synthesized via a chiral precursor. The changes in the absorption and CD spectra upon binding provide detailed information about DNA binding of the enantiomers. The change in the CD spectra over time was used to calculate the racemization rates in the absence and presence of DNA. It was observed that the Δ-enantiomer racemizes slower than the Λ-enantiomer in the presence of DNA. Competition between the Ru(II) enantiomers, Δ- and Λ-[Ru(phen)2(dppz)] 2+, and the Ni(II) enantiomers, Δ- and Λ-[Ni(phen) 2(dppz)]2+, was also studied via luminescence titration.",

keywords = "Chiral precursor, Circular dichroism (CD), DNA binding, Dipyrido[3,2-a:2′,3′-c]phenazine (dppz), Enantiomer, Nickel(II) complex",

author = "Hassan Hadadzadeh and Marzieh Daryanavard and Mahbod Morshedi",

year = "2013",

month = may,

day = "1",

doi = "10.1016/j.ica.2013.02.010",

language = "English",

volume = "400",

pages = "82--90",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Interaction of mononuclear nickel(II) enantiomers, Δ- And Λ-bis(1,10-phenanthroline) (dipyrido[3,2-a:2′,3′-c]phenazine) nickel(II) chloride, with calf thymus DNA

AU - Hadadzadeh, Hassan

AU - Daryanavard, Marzieh

AU - Morshedi, Mahbod

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Circular dichroism (CD) spectroscopy was used to investigate the interaction of Δ- and Λ-enantiomers of a mononuclear Ni(II) complex, [Ni(phen)2(dppz)]2+ (where phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2′,3′-c]phenazine), with CT-DNA. The pure Ni(II) enantiomers were synthesized via a chiral precursor. The changes in the absorption and CD spectra upon binding provide detailed information about DNA binding of the enantiomers. The change in the CD spectra over time was used to calculate the racemization rates in the absence and presence of DNA. It was observed that the Δ-enantiomer racemizes slower than the Λ-enantiomer in the presence of DNA. Competition between the Ru(II) enantiomers, Δ- and Λ-[Ru(phen)2(dppz)] 2+, and the Ni(II) enantiomers, Δ- and Λ-[Ni(phen) 2(dppz)]2+, was also studied via luminescence titration.

AB - Circular dichroism (CD) spectroscopy was used to investigate the interaction of Δ- and Λ-enantiomers of a mononuclear Ni(II) complex, [Ni(phen)2(dppz)]2+ (where phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2′,3′-c]phenazine), with CT-DNA. The pure Ni(II) enantiomers were synthesized via a chiral precursor. The changes in the absorption and CD spectra upon binding provide detailed information about DNA binding of the enantiomers. The change in the CD spectra over time was used to calculate the racemization rates in the absence and presence of DNA. It was observed that the Δ-enantiomer racemizes slower than the Λ-enantiomer in the presence of DNA. Competition between the Ru(II) enantiomers, Δ- and Λ-[Ru(phen)2(dppz)] 2+, and the Ni(II) enantiomers, Δ- and Λ-[Ni(phen) 2(dppz)]2+, was also studied via luminescence titration.

KW - Chiral precursor

KW - Circular dichroism (CD)

KW - DNA binding

KW - Dipyrido[3,2-a:2′,3′-c]phenazine (dppz)

KW - Enantiomer

KW - Nickel(II) complex

UR - https://www.scopus.com/pages/publications/84875388488

U2 - 10.1016/j.ica.2013.02.010

DO - 10.1016/j.ica.2013.02.010

M3 - Article

SN - 0020-1693

VL - 400

SP - 82

EP - 90

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Interaction of mononuclear nickel(II) enantiomers, Δ- And Λ-bis(1,10-phenanthroline) (dipyrido[3,2-a:2′,3′-c]phenazine) nickel(II) chloride, with calf thymus DNA

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