Interindividual variation in epigenomic phenomena in humans

Hugh J. French; Rosalind Attenborough; Kristine Hardy; M. Frances Shannon; Rohan B.H. Williams

doi:10.1007/s00335-009-9219-0

Interindividual variation in epigenomic phenomena in humans

Hugh J. French, Rosalind Attenborough, Kristine Hardy, M. Frances Shannon, Rohan B.H. Williams

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Our knowledge of regulatory mechanisms of gene expression and other chromosomal processes related to DNA methylation and chromatin state is continuing to grow at a rapid pace. Understanding how these epigenomic phenomena vary between individuals will have an impact on understanding their broader role in determining variation in gene expression and biochemical, physiological, and behavioural phenotypes. In this review we survey recent progress in this area, focusing on data available from humans. We highlight the role of obligatory (sequence-dependent) epigenomic variation as an important mechanism for generating interindividual variation that could impact our understanding of the mechanistic basis of complex trait architecture.

Original language	English
Pages (from-to)	604-611
Number of pages	8
Journal	Mammalian Genome
Volume	20
Issue number	9-10
DOIs	https://doi.org/10.1007/s00335-009-9219-0
Publication status	Published - Oct 2009

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AU - French, Hugh J.

AU - Attenborough, Rosalind

AU - Hardy, Kristine

AU - Shannon, M. Frances

AU - Williams, Rohan B.H.

PY - 2009/10

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N2 - Our knowledge of regulatory mechanisms of gene expression and other chromosomal processes related to DNA methylation and chromatin state is continuing to grow at a rapid pace. Understanding how these epigenomic phenomena vary between individuals will have an impact on understanding their broader role in determining variation in gene expression and biochemical, physiological, and behavioural phenotypes. In this review we survey recent progress in this area, focusing on data available from humans. We highlight the role of obligatory (sequence-dependent) epigenomic variation as an important mechanism for generating interindividual variation that could impact our understanding of the mechanistic basis of complex trait architecture.

AB - Our knowledge of regulatory mechanisms of gene expression and other chromosomal processes related to DNA methylation and chromatin state is continuing to grow at a rapid pace. Understanding how these epigenomic phenomena vary between individuals will have an impact on understanding their broader role in determining variation in gene expression and biochemical, physiological, and behavioural phenotypes. In this review we survey recent progress in this area, focusing on data available from humans. We highlight the role of obligatory (sequence-dependent) epigenomic variation as an important mechanism for generating interindividual variation that could impact our understanding of the mechanistic basis of complex trait architecture.

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U2 - 10.1007/s00335-009-9219-0

DO - 10.1007/s00335-009-9219-0

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JO - Mammalian Genome

JF - Mammalian Genome

IS - 9-10

ER -

Interindividual variation in epigenomic phenomena in humans

Abstract

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