Intramolecular DNA coiling mediated by a metallo-supramolecular cylinder

Michael J. Hannon; Virtudes Moreno; Maria J. Prieto; Erlend Moldrheim; Einar Sletten; Isabelle Meistermann; Christian J. Isaac; Karen J. Sanders; Alison Rodger

doi:10.1002/1521-3773(20010302)40:5<879::aid-anie879>3.0.co;2-x

Intramolecular DNA coiling mediated by a metallo-supramolecular cylinder

Michael J. Hannon^*, Virtudes Moreno, Maria J. Prieto, Erlend Moldrheim, Einar Sletten, Isabelle Meistermann, Christian J. Isaac, Karen J. Sanders, Alison Rodger

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

In the groove! A tetracationic supramolecular cylinder, [Fe₂L₃]⁴⁺ (L = C₂₅H₂₀N₄), with a triplehelical architecture is just the right size to fit into the major groove of DNA (see picture) and too big to fit in to the minor groove. NMR spectroscopic data confirm that the cylinder binds in the major groove. Linear dichroism shows that very low loadings of [Fe₂L₃]⁴⁺ have a dramatic bending effect on the DNA and atomic force microscopy images show that this is an intramolecular effect resulting in coils of DNA.

Original language	English
Pages (from-to)	879-884
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	5
DOIs	https://doi.org/10.1002/1521-3773(20010302)40:5<879::aid-anie879>3.0.co;2-x
Publication status	Published - 2 Mar 2001
Externally published	Yes

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title = "Intramolecular DNA coiling mediated by a metallo-supramolecular cylinder",

abstract = "In the groove! A tetracationic supramolecular cylinder, [Fe2L3]4+ (L = C25H20N4), with a triplehelical architecture is just the right size to fit into the major groove of DNA (see picture) and too big to fit in to the minor groove. NMR spectroscopic data confirm that the cylinder binds in the major groove. Linear dichroism shows that very low loadings of [Fe2L3]4+ have a dramatic bending effect on the DNA and atomic force microscopy images show that this is an intramolecular effect resulting in coils of DNA.",

keywords = "Bioinorganic chemistry, DNA recognition, DNA structure, Helical structures, Supramolecular chemistry",

author = "Hannon, {Michael J.} and Virtudes Moreno and Prieto, {Maria J.} and Erlend Moldrheim and Einar Sletten and Isabelle Meistermann and Isaac, {Christian J.} and Sanders, {Karen J.} and Alison Rodger",

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doi = "10.1002/1521-3773(20010302)40:5<879::aid-anie879>3.0.co;2-x",

language = "English",

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journal = "Angewandte Chemie - International Edition",

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T1 - Intramolecular DNA coiling mediated by a metallo-supramolecular cylinder

AU - Hannon, Michael J.

AU - Moreno, Virtudes

AU - Prieto, Maria J.

AU - Moldrheim, Erlend

AU - Sletten, Einar

AU - Meistermann, Isabelle

AU - Isaac, Christian J.

AU - Sanders, Karen J.

AU - Rodger, Alison

PY - 2001/3/2

Y1 - 2001/3/2

N2 - In the groove! A tetracationic supramolecular cylinder, [Fe2L3]4+ (L = C25H20N4), with a triplehelical architecture is just the right size to fit into the major groove of DNA (see picture) and too big to fit in to the minor groove. NMR spectroscopic data confirm that the cylinder binds in the major groove. Linear dichroism shows that very low loadings of [Fe2L3]4+ have a dramatic bending effect on the DNA and atomic force microscopy images show that this is an intramolecular effect resulting in coils of DNA.

AB - In the groove! A tetracationic supramolecular cylinder, [Fe2L3]4+ (L = C25H20N4), with a triplehelical architecture is just the right size to fit into the major groove of DNA (see picture) and too big to fit in to the minor groove. NMR spectroscopic data confirm that the cylinder binds in the major groove. Linear dichroism shows that very low loadings of [Fe2L3]4+ have a dramatic bending effect on the DNA and atomic force microscopy images show that this is an intramolecular effect resulting in coils of DNA.

KW - Bioinorganic chemistry

KW - DNA recognition

KW - DNA structure

KW - Helical structures

KW - Supramolecular chemistry

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M3 - Article

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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Intramolecular DNA coiling mediated by a metallo-supramolecular cylinder

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