Intratumoral T cells have a differential impact on FDG-PET parameters in follicular lymphoma

Karthik Nath; Soi Cheng Law; Muhammed B. Sabdia; Jay Gunawardana; Lilia M. De Long; David Sester; Mohamed Shanavas; Hennes Tsang; Joshua W.D. Tobin; Sarah Jane Halliday; Annette Hernandez; Donna Cross; Robert J. Bird; Sanjiv Jain; Colm Keane; Dipti Talaulikar; Judith Trotman; Phillip Law; Maher K. Gandhi

doi:10.1182/bloodadvances.2020004051

Intratumoral T cells have a differential impact on FDG-PET parameters in follicular lymphoma

Karthik Nath^*, Soi Cheng Law, Muhammed B. Sabdia, Jay Gunawardana, Lilia M. De Long, David Sester, Mohamed Shanavas, Hennes Tsang, Joshua W.D. Tobin, Sarah Jane Halliday, Annette Hernandez, Donna Cross, Robert J. Bird, Sanjiv Jain, Colm Keane, Dipti Talaulikar, Judith Trotman, Phillip Law, Maher K. Gandhi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Data on the prognostic impact of pretherapy 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in follicular lymphoma (FL) is conflicting. The predictive utility of pretherapy total metabolic tumor volume (TMTV) and maximum standardized uptake value (SUVmax) on outcome appears to vary between regimens. Chemoimmunotherapies vary in the extent of T-cell depletion they induce. The role of intratumoral T cells on pretherapy FDG-PET parameters is undefined. We assessed pretherapy FDG-PET parameters and quantified intratumoral T cells by multiple methodologies. Low intratumoral T cells associated with approximately sixfold higher TMTV, and FL nodes from patients with high TMTV showed increased malignant B-cell infiltration and fewer clonally expanded intratumoral CD81 and CD41 T-follicular helper cells than those with low TMTV. However, fluorescently labeled glucose uptake was higher in CD41 and CD81 T cells than intratumoral B cells. In patients with FDG-PET performed prior to excisional biopsy, SUVmax within the subsequently excised node associated with T cells but not B cells. In summary, TMTV best reflects the malignant B-cell burden in FL, whereas intratumoral T cells influence SUVmax. This may contribute to the contradictory results between the prognostic role of different FDG-PET parameters, particularly between short-and long-Term T-cell depleting chemoimmunotherapeutic regimens. The impact of glucose uptake in intratumoral T cells should be considered when interpreting pretherapy FDG-PET in FL.

Original language	English
Pages (from-to)	2644-2649
Number of pages	6
Journal	Blood advances
Volume	5
Issue number	12
DOIs	https://doi.org/10.1182/bloodadvances.2020004051
Publication status	Published - 22 Jun 2021

Access to Document

10.1182/bloodadvances.2020004051

Cite this

Nath, K., Law, S. C., Sabdia, M. B., Gunawardana, J., De Long, L. M., Sester, D., Shanavas, M., Tsang, H., Tobin, J. W. D., Halliday, S. J., Hernandez, A., Cross, D., Bird, R. J., Jain, S., Keane, C., Talaulikar, D., Trotman, J., Law, P., & Gandhi, M. K. (2021). Intratumoral T cells have a differential impact on FDG-PET parameters in follicular lymphoma. Blood advances, 5(12), 2644-2649. https://doi.org/10.1182/bloodadvances.2020004051

@article{0668f379738a418ebd0d912f1bec5144,

title = "Intratumoral T cells have a differential impact on FDG-PET parameters in follicular lymphoma",

abstract = "Data on the prognostic impact of pretherapy 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in follicular lymphoma (FL) is conflicting. The predictive utility of pretherapy total metabolic tumor volume (TMTV) and maximum standardized uptake value (SUVmax) on outcome appears to vary between regimens. Chemoimmunotherapies vary in the extent of T-cell depletion they induce. The role of intratumoral T cells on pretherapy FDG-PET parameters is undefined. We assessed pretherapy FDG-PET parameters and quantified intratumoral T cells by multiple methodologies. Low intratumoral T cells associated with approximately sixfold higher TMTV, and FL nodes from patients with high TMTV showed increased malignant B-cell infiltration and fewer clonally expanded intratumoral CD81 and CD41 T-follicular helper cells than those with low TMTV. However, fluorescently labeled glucose uptake was higher in CD41 and CD81 T cells than intratumoral B cells. In patients with FDG-PET performed prior to excisional biopsy, SUVmax within the subsequently excised node associated with T cells but not B cells. In summary, TMTV best reflects the malignant B-cell burden in FL, whereas intratumoral T cells influence SUVmax. This may contribute to the contradictory results between the prognostic role of different FDG-PET parameters, particularly between short-and long-Term T-cell depleting chemoimmunotherapeutic regimens. The impact of glucose uptake in intratumoral T cells should be considered when interpreting pretherapy FDG-PET in FL.",

author = "Karthik Nath and Law, {Soi Cheng} and Sabdia, {Muhammed B.} and Jay Gunawardana and {De Long}, {Lilia M.} and David Sester and Mohamed Shanavas and Hennes Tsang and Tobin, {Joshua W.D.} and Halliday, {Sarah Jane} and Annette Hernandez and Donna Cross and Bird, {Robert J.} and Sanjiv Jain and Colm Keane and Dipti Talaulikar and Judith Trotman and Phillip Law and Gandhi, {Maher K.}",

year = "2021",

month = jun,

day = "22",

doi = "10.1182/bloodadvances.2020004051",

language = "English",

volume = "5",

pages = "2644--2649",

journal = "Blood advances",

issn = "2473-9529",

publisher = "Elsevier B.V.",

number = "12",

}

Nath, K, Law, SC, Sabdia, MB, Gunawardana, J, De Long, LM, Sester, D, Shanavas, M, Tsang, H, Tobin, JWD, Halliday, SJ, Hernandez, A, Cross, D, Bird, RJ, Jain, S, Keane, C, Talaulikar, D, Trotman, J, Law, P & Gandhi, MK 2021, 'Intratumoral T cells have a differential impact on FDG-PET parameters in follicular lymphoma', Blood advances, vol. 5, no. 12, pp. 2644-2649. https://doi.org/10.1182/bloodadvances.2020004051

TY - JOUR

T1 - Intratumoral T cells have a differential impact on FDG-PET parameters in follicular lymphoma

AU - Nath, Karthik

AU - Law, Soi Cheng

AU - Sabdia, Muhammed B.

AU - Gunawardana, Jay

AU - De Long, Lilia M.

AU - Sester, David

AU - Shanavas, Mohamed

AU - Tsang, Hennes

AU - Tobin, Joshua W.D.

AU - Halliday, Sarah Jane

AU - Hernandez, Annette

AU - Cross, Donna

AU - Bird, Robert J.

AU - Jain, Sanjiv

AU - Keane, Colm

AU - Talaulikar, Dipti

AU - Trotman, Judith

AU - Law, Phillip

AU - Gandhi, Maher K.

PY - 2021/6/22

Y1 - 2021/6/22

N2 - Data on the prognostic impact of pretherapy 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in follicular lymphoma (FL) is conflicting. The predictive utility of pretherapy total metabolic tumor volume (TMTV) and maximum standardized uptake value (SUVmax) on outcome appears to vary between regimens. Chemoimmunotherapies vary in the extent of T-cell depletion they induce. The role of intratumoral T cells on pretherapy FDG-PET parameters is undefined. We assessed pretherapy FDG-PET parameters and quantified intratumoral T cells by multiple methodologies. Low intratumoral T cells associated with approximately sixfold higher TMTV, and FL nodes from patients with high TMTV showed increased malignant B-cell infiltration and fewer clonally expanded intratumoral CD81 and CD41 T-follicular helper cells than those with low TMTV. However, fluorescently labeled glucose uptake was higher in CD41 and CD81 T cells than intratumoral B cells. In patients with FDG-PET performed prior to excisional biopsy, SUVmax within the subsequently excised node associated with T cells but not B cells. In summary, TMTV best reflects the malignant B-cell burden in FL, whereas intratumoral T cells influence SUVmax. This may contribute to the contradictory results between the prognostic role of different FDG-PET parameters, particularly between short-and long-Term T-cell depleting chemoimmunotherapeutic regimens. The impact of glucose uptake in intratumoral T cells should be considered when interpreting pretherapy FDG-PET in FL.

AB - Data on the prognostic impact of pretherapy 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in follicular lymphoma (FL) is conflicting. The predictive utility of pretherapy total metabolic tumor volume (TMTV) and maximum standardized uptake value (SUVmax) on outcome appears to vary between regimens. Chemoimmunotherapies vary in the extent of T-cell depletion they induce. The role of intratumoral T cells on pretherapy FDG-PET parameters is undefined. We assessed pretherapy FDG-PET parameters and quantified intratumoral T cells by multiple methodologies. Low intratumoral T cells associated with approximately sixfold higher TMTV, and FL nodes from patients with high TMTV showed increased malignant B-cell infiltration and fewer clonally expanded intratumoral CD81 and CD41 T-follicular helper cells than those with low TMTV. However, fluorescently labeled glucose uptake was higher in CD41 and CD81 T cells than intratumoral B cells. In patients with FDG-PET performed prior to excisional biopsy, SUVmax within the subsequently excised node associated with T cells but not B cells. In summary, TMTV best reflects the malignant B-cell burden in FL, whereas intratumoral T cells influence SUVmax. This may contribute to the contradictory results between the prognostic role of different FDG-PET parameters, particularly between short-and long-Term T-cell depleting chemoimmunotherapeutic regimens. The impact of glucose uptake in intratumoral T cells should be considered when interpreting pretherapy FDG-PET in FL.

UR - http://www.scopus.com/inward/record.url?scp=85108694795&partnerID=8YFLogxK

U2 - 10.1182/bloodadvances.2020004051

DO - 10.1182/bloodadvances.2020004051

M3 - Article

SN - 2473-9529

VL - 5

SP - 2644

EP - 2649

JO - Blood advances

JF - Blood advances

IS - 12

ER -

Intratumoral T cells have a differential impact on FDG-PET parameters in follicular lymphoma

Abstract

Access to Document

Other files and links

Fingerprint

Cite this