Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids

Craig M. Williams; Lewis N. Mander; Paul V. Bernhardt; Anthony C. Willis

doi:10.1016/j.tet.2005.02.014

Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids

Craig M. Williams^*, Lewis N. Mander, Paul V. Bernhardt, Anthony C. Willis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Rapid access to the ABCE ring system of the C-20 diterpene alkaloids was achieved by silver (I) promoted intramolecular Friedel-Crafts arylation of a functional group specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.

Original language	English
Pages (from-to)	3759-3769
Number of pages	11
Journal	Tetrahedron
Volume	61
Issue number	15
DOIs	https://doi.org/10.1016/j.tet.2005.02.014
Publication status	Published - 11 Apr 2005

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10.1016/j.tet.2005.02.014

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title = "Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids",

abstract = "Rapid access to the ABCE ring system of the C-20 diterpene alkaloids was achieved by silver (I) promoted intramolecular Friedel-Crafts arylation of a functional group specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.",

keywords = "3-Azabicyclo[3.3.1]nonane, Diterpene alkaloids, Intramolecular Friedel-Crafts arylation, Silver (I)",

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doi = "10.1016/j.tet.2005.02.014",

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T1 - Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids

AU - Williams, Craig M.

AU - Mander, Lewis N.

AU - Bernhardt, Paul V.

AU - Willis, Anthony C.

PY - 2005/4/11

Y1 - 2005/4/11

N2 - Rapid access to the ABCE ring system of the C-20 diterpene alkaloids was achieved by silver (I) promoted intramolecular Friedel-Crafts arylation of a functional group specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.

AB - Rapid access to the ABCE ring system of the C-20 diterpene alkaloids was achieved by silver (I) promoted intramolecular Friedel-Crafts arylation of a functional group specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.

KW - 3-Azabicyclo[3.3.1]nonane

KW - Diterpene alkaloids

KW - Intramolecular Friedel-Crafts arylation

KW - Silver (I)

UR - https://www.scopus.com/pages/publications/15044357224

U2 - 10.1016/j.tet.2005.02.014

DO - 10.1016/j.tet.2005.02.014

M3 - Article

SN - 0040-4020

VL - 61

SP - 3759

EP - 3769

JO - Tetrahedron

JF - Tetrahedron

IS - 15

ER -

Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids

Abstract

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