TY - JOUR
T1 - Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands
AU - Pages, Benjamin J.
AU - Sakoff, Jennette
AU - Gilbert, Jayne
AU - Zhang, Yingjie
AU - Li, Feng
AU - Preston, Dan
AU - Crowley, James D.
AU - Aldrich-Wright, Janice R.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Six platinum(II) complexes of the type [Pt(PL)(AL)]2 +, where PL is a bidentate pyridyl-1,2,3-triazole “click” ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.
AB - Six platinum(II) complexes of the type [Pt(PL)(AL)]2 +, where PL is a bidentate pyridyl-1,2,3-triazole “click” ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.
KW - Cell growth inhibition
KW - Click
KW - Platinum
KW - Triazole
KW - X-ray crystal structure
UR - http://www.scopus.com/inward/record.url?scp=84977108959&partnerID=8YFLogxK
U2 - 10.1016/j.jinorgbio.2016.06.017
DO - 10.1016/j.jinorgbio.2016.06.017
M3 - Article
SN - 0162-0134
VL - 165
SP - 92
EP - 99
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
ER -