Abstract
Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 Å resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.
Original language | English |
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Pages (from-to) | 283-293 |
Number of pages | 11 |
Journal | European Biophysics Journal |
Volume | 31 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 2002 |