Ion channels: Recent progress and prospects

Shin Ho Chung; Serdar Kuyucak

doi:10.1007/s00249-002-0216-4

Ion channels: Recent progress and prospects

Shin Ho Chung^*, Serdar Kuyucak

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

38 Citations (Scopus)

Abstract

Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 Å resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.

Original language	English
Pages (from-to)	283-293
Number of pages	11
Journal	European Biophysics Journal
Volume	31
Issue number	4
DOIs	https://doi.org/10.1007/s00249-002-0216-4
Publication status	Published - Jul 2002

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title = "Ion channels: Recent progress and prospects",

abstract = "Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 {\AA} resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.",

keywords = "Brownian dynamics, Ion channels, Molecular dynamics, Potassium channels",

author = "Chung, {Shin Ho} and Serdar Kuyucak",

year = "2002",

month = jul,

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language = "English",

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journal = "European Biophysics Journal",

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T2 - Recent progress and prospects

AU - Chung, Shin Ho

AU - Kuyucak, Serdar

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N2 - Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 Å resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.

AB - Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 Å resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.

KW - Brownian dynamics

KW - Ion channels

KW - Molecular dynamics

KW - Potassium channels

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U2 - 10.1007/s00249-002-0216-4

DO - 10.1007/s00249-002-0216-4

M3 - Review article

SN - 0175-7571

VL - 31

SP - 283

EP - 293

JO - European Biophysics Journal

JF - European Biophysics Journal

IS - 4

ER -

Ion channels: Recent progress and prospects

Abstract

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