Ion channels: Recent progress and prospects

Shin Ho Chung; Serdar Kuyucak

doi:10.1007/s00249-002-0216-4

Ion channels: Recent progress and prospects

Shin Ho Chung^*
, Serdar Kuyucak

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

40 Citations (Scopus)

Abstract

Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 Å resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.

Original language	English
Pages (from-to)	283-293
Number of pages	11
Journal	European Biophysics Journal
Volume	31
Issue number	4
DOIs	https://doi.org/10.1007/s00249-002-0216-4
Publication status	Published - Jul 2002

Access to Document

10.1007/s00249-002-0216-4

Cite this

@article{2bc6ed4e704c4f39b1c4d0043cd13525,

title = "Ion channels: Recent progress and prospects",

abstract = "Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 {\AA} resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.",

keywords = "Brownian dynamics, Ion channels, Molecular dynamics, Potassium channels",

author = "Chung, \{Shin Ho\} and Serdar Kuyucak",

year = "2002",

month = jul,

doi = "10.1007/s00249-002-0216-4",

language = "English",

volume = "31",

pages = "283--293",

journal = "European Biophysics Journal",

issn = "0175-7571",

publisher = "Springer Science+Business Media B.V.",

number = "4",

}

TY - JOUR

T1 - Ion channels

T2 - Recent progress and prospects

AU - Chung, Shin Ho

AU - Kuyucak, Serdar

PY - 2002/7

Y1 - 2002/7

N2 - Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 Å resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.

AB - Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 Å resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.

KW - Brownian dynamics

KW - Ion channels

KW - Molecular dynamics

KW - Potassium channels

UR - https://www.scopus.com/pages/publications/0036656435

U2 - 10.1007/s00249-002-0216-4

DO - 10.1007/s00249-002-0216-4

M3 - Review article

SN - 0175-7571

VL - 31

SP - 283

EP - 293

JO - European Biophysics Journal

JF - European Biophysics Journal

IS - 4

ER -

Ion channels: Recent progress and prospects

Abstract

Access to Document

Other files and links

Fingerprint

Cite this