Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients

Nagisa Sugaya; Eiji Yoshida; Shin Yasuda; Mamoru Tochigi; Kunio Takei; Toshiyuki Ohtani; Takeshi Otowa; Takanobu Minato; Tadashi Umekage; Yuji Sakano; Junwen Chen; Hironori Shimada; Shinobu Nomura; Yuji Okazaki; Hisanobu Kaiya; Hisashi Tanii; Tsukasa Sasaki

doi:10.1111/pcn.12069

Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients

Nagisa Sugaya^*, Eiji Yoshida, Shin Yasuda, Mamoru Tochigi, Kunio Takei, Toshiyuki Ohtani, Takeshi Otowa, Takanobu Minato, Tadashi Umekage, Yuji Sakano, Junwen Chen, Hironori Shimada, Shinobu Nomura, Yuji Okazaki, Hisanobu Kaiya, Hisashi Tanii, Tsukasa Sasaki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Aim The present study examined the effect of irritable bowel syndrome (IBS), cognitive appraisal of IBS, and anxiety sensitivity on anticipatory anxiety (AA) and agoraphobia (AG) in patients with panic disorder (PD). Methods We examined 244 PD patients who completed a set of questionnaires that included the Rome II Modular Questionnaire to assess the presence of IBS, the Anxiety Sensitivity Index (ASI), the Cognitive Appraisal Rating Scale (CARS; assessing the cognitive appraisal of abdominal symptoms in four dimensions: commitment, appraisal of effect, appraisal of threat, and controllability), and items about the severity of AA and AG. The Mini International Neuropsychiatric Interview was used to diagnose AG and PD. Results After excluding individuals with possible organic gastrointestinal diseases by using 'red flag items,' valid data were obtained from 174 participants, including 110 PD patients without IBS (PD/IBS[-]) and 64 with IBS (PD/IBS[+]). The PD/IBS[+] group had higher AA and higher comorbidity with AG than the PD/IBS[-] group. In the PD/IBS[+] group, the controllability score of CARS was significantly correlated with AA and ASI. Multiple regression analysis showed a significant effect of ASI but not of controllability on AA in PD/IBS[+] subjects. Conclusion This study suggested that the presence of IBS may be related to agoraphobia and anticipatory anxiety in PD patients. Cognitive appraisal could be partly related to anticipatory anxiety in PD patients with IBS with anxiety sensitivity mediating this correlation.

Original language	English
Pages (from-to)	397-404
Number of pages	8
Journal	Psychiatry and Clinical Neurosciences
Volume	67
Issue number	6
DOIs	https://doi.org/10.1111/pcn.12069
Publication status	Published - Sept 2013
Externally published	Yes

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Sugaya, N., Yoshida, E., Yasuda, S., Tochigi, M., Takei, K., Ohtani, T., Otowa, T., Minato, T., Umekage, T., Sakano, Y., Chen, J., Shimada, H., Nomura, S., Okazaki, Y., Kaiya, H., Tanii, H., & Sasaki, T. (2013). Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients. Psychiatry and Clinical Neurosciences, 67(6), 397-404. https://doi.org/10.1111/pcn.12069

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title = "Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients",

abstract = "Aim The present study examined the effect of irritable bowel syndrome (IBS), cognitive appraisal of IBS, and anxiety sensitivity on anticipatory anxiety (AA) and agoraphobia (AG) in patients with panic disorder (PD). Methods We examined 244 PD patients who completed a set of questionnaires that included the Rome II Modular Questionnaire to assess the presence of IBS, the Anxiety Sensitivity Index (ASI), the Cognitive Appraisal Rating Scale (CARS; assessing the cognitive appraisal of abdominal symptoms in four dimensions: commitment, appraisal of effect, appraisal of threat, and controllability), and items about the severity of AA and AG. The Mini International Neuropsychiatric Interview was used to diagnose AG and PD. Results After excluding individuals with possible organic gastrointestinal diseases by using 'red flag items,' valid data were obtained from 174 participants, including 110 PD patients without IBS (PD/IBS[-]) and 64 with IBS (PD/IBS[+]). The PD/IBS[+] group had higher AA and higher comorbidity with AG than the PD/IBS[-] group. In the PD/IBS[+] group, the controllability score of CARS was significantly correlated with AA and ASI. Multiple regression analysis showed a significant effect of ASI but not of controllability on AA in PD/IBS[+] subjects. Conclusion This study suggested that the presence of IBS may be related to agoraphobia and anticipatory anxiety in PD patients. Cognitive appraisal could be partly related to anticipatory anxiety in PD patients with IBS with anxiety sensitivity mediating this correlation.",

keywords = "anxiety, cognitive factors, irritable bowel syndrome, panic disorder",

author = "Nagisa Sugaya and Eiji Yoshida and Shin Yasuda and Mamoru Tochigi and Kunio Takei and Toshiyuki Ohtani and Takeshi Otowa and Takanobu Minato and Tadashi Umekage and Yuji Sakano and Junwen Chen and Hironori Shimada and Shinobu Nomura and Yuji Okazaki and Hisanobu Kaiya and Hisashi Tanii and Tsukasa Sasaki",

year = "2013",

month = sep,

doi = "10.1111/pcn.12069",

language = "English",

volume = "67",

pages = "397--404",

journal = "Psychiatry and Clinical Neurosciences",

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Sugaya, N, Yoshida, E, Yasuda, S, Tochigi, M, Takei, K, Ohtani, T, Otowa, T, Minato, T, Umekage, T, Sakano, Y, Chen, J, Shimada, H, Nomura, S, Okazaki, Y, Kaiya, H, Tanii, H & Sasaki, T 2013, 'Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients', Psychiatry and Clinical Neurosciences, vol. 67, no. 6, pp. 397-404. https://doi.org/10.1111/pcn.12069

TY - JOUR

T1 - Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients

AU - Sugaya, Nagisa

AU - Yoshida, Eiji

AU - Yasuda, Shin

AU - Tochigi, Mamoru

AU - Takei, Kunio

AU - Ohtani, Toshiyuki

AU - Otowa, Takeshi

AU - Minato, Takanobu

AU - Umekage, Tadashi

AU - Sakano, Yuji

AU - Chen, Junwen

AU - Shimada, Hironori

AU - Nomura, Shinobu

AU - Okazaki, Yuji

AU - Kaiya, Hisanobu

AU - Tanii, Hisashi

AU - Sasaki, Tsukasa

PY - 2013/9

Y1 - 2013/9

N2 - Aim The present study examined the effect of irritable bowel syndrome (IBS), cognitive appraisal of IBS, and anxiety sensitivity on anticipatory anxiety (AA) and agoraphobia (AG) in patients with panic disorder (PD). Methods We examined 244 PD patients who completed a set of questionnaires that included the Rome II Modular Questionnaire to assess the presence of IBS, the Anxiety Sensitivity Index (ASI), the Cognitive Appraisal Rating Scale (CARS; assessing the cognitive appraisal of abdominal symptoms in four dimensions: commitment, appraisal of effect, appraisal of threat, and controllability), and items about the severity of AA and AG. The Mini International Neuropsychiatric Interview was used to diagnose AG and PD. Results After excluding individuals with possible organic gastrointestinal diseases by using 'red flag items,' valid data were obtained from 174 participants, including 110 PD patients without IBS (PD/IBS[-]) and 64 with IBS (PD/IBS[+]). The PD/IBS[+] group had higher AA and higher comorbidity with AG than the PD/IBS[-] group. In the PD/IBS[+] group, the controllability score of CARS was significantly correlated with AA and ASI. Multiple regression analysis showed a significant effect of ASI but not of controllability on AA in PD/IBS[+] subjects. Conclusion This study suggested that the presence of IBS may be related to agoraphobia and anticipatory anxiety in PD patients. Cognitive appraisal could be partly related to anticipatory anxiety in PD patients with IBS with anxiety sensitivity mediating this correlation.

AB - Aim The present study examined the effect of irritable bowel syndrome (IBS), cognitive appraisal of IBS, and anxiety sensitivity on anticipatory anxiety (AA) and agoraphobia (AG) in patients with panic disorder (PD). Methods We examined 244 PD patients who completed a set of questionnaires that included the Rome II Modular Questionnaire to assess the presence of IBS, the Anxiety Sensitivity Index (ASI), the Cognitive Appraisal Rating Scale (CARS; assessing the cognitive appraisal of abdominal symptoms in four dimensions: commitment, appraisal of effect, appraisal of threat, and controllability), and items about the severity of AA and AG. The Mini International Neuropsychiatric Interview was used to diagnose AG and PD. Results After excluding individuals with possible organic gastrointestinal diseases by using 'red flag items,' valid data were obtained from 174 participants, including 110 PD patients without IBS (PD/IBS[-]) and 64 with IBS (PD/IBS[+]). The PD/IBS[+] group had higher AA and higher comorbidity with AG than the PD/IBS[-] group. In the PD/IBS[+] group, the controllability score of CARS was significantly correlated with AA and ASI. Multiple regression analysis showed a significant effect of ASI but not of controllability on AA in PD/IBS[+] subjects. Conclusion This study suggested that the presence of IBS may be related to agoraphobia and anticipatory anxiety in PD patients. Cognitive appraisal could be partly related to anticipatory anxiety in PD patients with IBS with anxiety sensitivity mediating this correlation.

KW - anxiety

KW - cognitive factors

KW - irritable bowel syndrome

KW - panic disorder

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U2 - 10.1111/pcn.12069

DO - 10.1111/pcn.12069

M3 - Article

SN - 1323-1316

VL - 67

SP - 397

EP - 404

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

IS - 6

ER -

Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients

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