Is telomere length a biomarker of aging? A review

Karen Anne Mather, Anthony Francis Jorm, Ruth Adeline Parslow, Helen Christensen

    Research output: Contribution to journalReview articlepeer-review

    319 Citations (Scopus)

    Abstract

    Telomeres, the DNA-protein structures located at the ends of chromosomes, have been proposed to act as a biomarker of aging. In this review, the human evidence that telomere length is a biomarker of aging is evaluated. Although telomere length is implicated in cellular aging, the evidence suggesting telomere length is a biomarker of aging in humans is equivocal. More studies examining the relationships between telomere length and mortality and with measures that decline with "normal" aging in community samples are required. These studies would benefit from longitudinal measures of both telomere length and aging-related parameters.

    Original languageEnglish
    Pages (from-to)202-213
    Number of pages12
    JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
    Volume66 A
    Issue number2
    DOIs
    Publication statusPublished - Feb 2011

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