Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?

Ian A. Clark*, Craig S. Atwood

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

This commentary addresses a novel mechanism by which aging-related changes in reproductive hormones could mediate their action in the brain. It presents the evidence that dyotic endocrine signals modulate the expression of tumor necrosis factor (TNF) and related cytokines, and that these cytokines are a functionally important downstream link mediating neurodegeneration and dysfunction. This convergence of dyotic signaling on TNF-mediated degeneration and dysfunction has important implications for understanding the pathophysiology of AD, stroke, and traumatic brain disease, and also for the treatment of these diseases.

Original languageEnglish
Pages (from-to)691-699
Number of pages9
JournalJournal of Alzheimer's Disease
Volume27
Issue number4
DOIs
Publication statusPublished - 2011

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