@article{1bdc95bafb25472dbed260ebb0298084,
title = "Islands of euchromatin-like sequence and expressed of polymorphic sequences within the short arm of human chromosome 21",
abstract = "The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the {"}heterochromatic{"} regions of the human genome is likely to reveal many additional functional elements and provide important evolutionary information.",
keywords = "Human acrocentric chromosomes, Human genome, Gene-expression, Satellite dna, Heterochromatin, Family, Region, Prediction, Subfamily, Software",
author = "Robert Lyle and Paola Prandini and Kazutoyo Osoegawa and {ten Hallers}, Boudewijn and Sean Humphray and Baoli Zhu and Eduardo Eyras and Robert Castelo and Bird, {Christine P.} and Sarantos Gagos and Carol Scott and Antony Cox and Samuel Deutsch and Catherine Ucla and Marc Cruts and Sophie Dahoun and Xinwei She and Frederique Bena and Sheng-Yue Wang and {Van Broeckhoven}, Christine and Eichler, {Evan E.} and Roderic Guigo and Jane Rogers and {de Jong}, {Pieter J.} and Alexandre Reymond and Antonarakis, {Stylianos E.}",
year = "2007",
month = nov,
doi = "10.1101/gr.6675307",
language = "English",
volume = "17",
pages = "1690--1696",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory Press",
number = "11",
}