It takes two transposons to tango: Transposable-element-mediated chromosomal rearrangements

Yasmine H.M. Gray

doi:10.1016/S0168-9525(00)02104-1

It takes two transposons to tango: Transposable-element-mediated chromosomal rearrangements

Yasmine H.M. Gray^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

261 Citations (Scopus)

Abstract

Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes^1-3. One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	461-468
Number of pages	8
Journal	Trends in Genetics
Volume	16
Issue number	10
DOIs	https://doi.org/10.1016/S0168-9525(00)02104-1
Publication status	Published - 1 Oct 2000

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title = "It takes two transposons to tango: Transposable-element-mediated chromosomal rearrangements",

abstract = "Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes1-3. One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool. Copyright (C) 2000 Elsevier Science Ltd.",

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N2 - Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes1-3. One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool. Copyright (C) 2000 Elsevier Science Ltd.

AB - Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes1-3. One explanation of such events is homologous recombination between multiple copies of a TE present in a genome. Although this does occur, strong evidence from a number of TE systems in bacteria, plants and animals suggests that another mechanism - alternative transposition - induces a large proportion of TE-associated chromosomal rearrangements. This paper reviews evidence for alternative transposition from a number of unrelated but structurally similar TEs. The similarities between alternative transposition and V(D)J recombination are also discussed, as is the use of alternative transposition as a genetic tool. Copyright (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034307716

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DO - 10.1016/S0168-9525(00)02104-1

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JO - Trends in Genetics

JF - Trends in Genetics

IS - 10

ER -

It takes two transposons to tango: Transposable-element-mediated chromosomal rearrangements

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