TY - JOUR
T1 - Kangaroo gene mapping and sequencing
T2 - Insights into mammalian genome evolution
AU - Graves, Jennifer A.Marshall
PY - 2013
Y1 - 2013
N2 - The deep divergence of marsupials and eutherian mammals 160million years ago provides genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. Following the pioneering work of Professor Desmond W. Cooper, emerging techniques in cytogenetics and molecular biology have been adapted to characterise the genomes of kangaroos and other marsupials. In particular, genetic and genomic work over four decades has shown that marsupial sex chromosomes differ significantly from the eutherian XY chromosome pair in their size, gene content and activity. These differences can be exploited to deduce how mammalian sex chromosomes, sex determination and epigenetic silencing evolved.
AB - The deep divergence of marsupials and eutherian mammals 160million years ago provides genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. Following the pioneering work of Professor Desmond W. Cooper, emerging techniques in cytogenetics and molecular biology have been adapted to characterise the genomes of kangaroos and other marsupials. In particular, genetic and genomic work over four decades has shown that marsupial sex chromosomes differ significantly from the eutherian XY chromosome pair in their size, gene content and activity. These differences can be exploited to deduce how mammalian sex chromosomes, sex determination and epigenetic silencing evolved.
UR - http://www.scopus.com/inward/record.url?scp=84880491247&partnerID=8YFLogxK
U2 - 10.1071/ZO13002
DO - 10.1071/ZO13002
M3 - Review article
SN - 0004-959X
VL - 61
SP - 4
EP - 12
JO - Australian Journal of Zoology
JF - Australian Journal of Zoology
IS - 1
ER -