Kangaroo gene mapping and sequencing: Insights into mammalian genome evolution

Jennifer A.Marshall Graves*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)

    Abstract

    The deep divergence of marsupials and eutherian mammals 160million years ago provides genetic variation to explore the evolution of DNA sequence, gene arrangement and regulation of gene expression in mammals. Following the pioneering work of Professor Desmond W. Cooper, emerging techniques in cytogenetics and molecular biology have been adapted to characterise the genomes of kangaroos and other marsupials. In particular, genetic and genomic work over four decades has shown that marsupial sex chromosomes differ significantly from the eutherian XY chromosome pair in their size, gene content and activity. These differences can be exploited to deduce how mammalian sex chromosomes, sex determination and epigenetic silencing evolved.

    Original languageEnglish
    Pages (from-to)4-12
    Number of pages9
    JournalAustralian Journal of Zoology
    Volume61
    Issue number1
    DOIs
    Publication statusPublished - 2013

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