Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: Results from a cross-sectional study of adults and a longitudinal study of children

Anthony F. Jorm; Margot Prior; Ann Sanson; Diana Smart; Yafei Zhang; Susan Tan; Simon Easteal

doi:10.1002/ajmg.10643

Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: Results from a cross-sectional study of adults and a longitudinal study of children

Anthony F. Jorm^*, Margot Prior, Ann Sanson, Diana Smart, Yafei Zhang, Susan Tan, Simon Easteal

^*Corresponding author for this work

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19 Citations (Scopus)

Abstract

There is evidence from animal experiments that the μ- and δ-opioid receptors may play a role in anxiety and depression. It might therefore be expected that functional polymorphisms of these genes in humans are associated with anxiety and depression. We investigated a single-nucleotide polymorphism (Asn40Asp) of the μ-opioid receptor gene (OPRM1). This association was investigated in two samples: 1) a cross-sectional survey of 867 community-living adults aged 18-79 years who were assessed for anxiety and depression symptoms and related personality traits; and 2) a longitudinal study of childhood temperament in which 660 children were followed from infancy to the mid-teens and assessed for anxiety-related temperament and behavior problems. The data did not support a role for the Asn40Asp polymorphism in anxiety and depression, despite adequate statistical power to detect small effects.

Original language	English
Pages (from-to)	659-664
Number of pages	6
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	114
Issue number	6
DOIs	https://doi.org/10.1002/ajmg.10643
Publication status	Published - 8 Aug 2002

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Jorm, A. F., Prior, M., Sanson, A., Smart, D., Zhang, Y., Tan, S., & Easteal, S. (2002). Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: Results from a cross-sectional study of adults and a longitudinal study of children. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 114(6), 659-664. https://doi.org/10.1002/ajmg.10643

Jorm, Anthony F. ; Prior, Margot ; Sanson, Ann et al. / Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits : Results from a cross-sectional study of adults and a longitudinal study of children. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2002 ; Vol. 114, No. 6. pp. 659-664.

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abstract = "There is evidence from animal experiments that the μ- and δ-opioid receptors may play a role in anxiety and depression. It might therefore be expected that functional polymorphisms of these genes in humans are associated with anxiety and depression. We investigated a single-nucleotide polymorphism (Asn40Asp) of the μ-opioid receptor gene (OPRM1). This association was investigated in two samples: 1) a cross-sectional survey of 867 community-living adults aged 18-79 years who were assessed for anxiety and depression symptoms and related personality traits; and 2) a longitudinal study of childhood temperament in which 660 children were followed from infancy to the mid-teens and assessed for anxiety-related temperament and behavior problems. The data did not support a role for the Asn40Asp polymorphism in anxiety and depression, despite adequate statistical power to detect small effects.",

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Jorm, AF, Prior, M, Sanson, A, Smart, D, Zhang, Y, Tan, S & Easteal, S 2002, 'Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: Results from a cross-sectional study of adults and a longitudinal study of children', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 114, no. 6, pp. 659-664. https://doi.org/10.1002/ajmg.10643

Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: Results from a cross-sectional study of adults and a longitudinal study of children. / Jorm, Anthony F.; Prior, Margot; Sanson, Ann et al.
In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 114, No. 6, 08.08.2002, p. 659-664.

Research output: Contribution to journal › Article › peer-review

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Jorm AF, Prior M, Sanson A, Smart D, Zhang Y, Tan S et al. Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: Results from a cross-sectional study of adults and a longitudinal study of children. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2002 Aug 8;114(6):659-664. doi: 10.1002/ajmg.10643

Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: Results from a cross-sectional study of adults and a longitudinal study of children

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