TY - JOUR
T1 - Left Atrial Reverse Remodeling
T2 - Mechanisms, Evaluation, and Clinical Significance
AU - Thomas, Liza
AU - Abhayaratna, Walter P.
N1 - Publisher Copyright:
© 2017 American College of Cardiology Foundation
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The left atrium is considered a biomarker for adverse cardiovascular outcomes, particularly in patients with left ventricular diastolic dysfunction and atrial fibrillation in whom left atrial (LA) enlargement is of prognostic importance. LA enlargement with a consequent decrease in LA function represents maladaptive structural and functional “remodeling” that in turn promotes electrical remodeling and a milieu conducive for incident atrial fibrillation. Medical and nonmedical interventions may arrest this pathophysiologic process to the extent that subsequent reverse remodeling results in a reduction in LA size and improvement in LA function. This review examines cellular and basic mechanisms involved in LA remodeling, evaluates the noninvasive techniques that can assess these changes, and examines potential mechanisms that may initiate reverse remodeling.
AB - The left atrium is considered a biomarker for adverse cardiovascular outcomes, particularly in patients with left ventricular diastolic dysfunction and atrial fibrillation in whom left atrial (LA) enlargement is of prognostic importance. LA enlargement with a consequent decrease in LA function represents maladaptive structural and functional “remodeling” that in turn promotes electrical remodeling and a milieu conducive for incident atrial fibrillation. Medical and nonmedical interventions may arrest this pathophysiologic process to the extent that subsequent reverse remodeling results in a reduction in LA size and improvement in LA function. This review examines cellular and basic mechanisms involved in LA remodeling, evaluates the noninvasive techniques that can assess these changes, and examines potential mechanisms that may initiate reverse remodeling.
KW - functional remodeling
KW - left atrium
KW - reverse remodeling
KW - structural remodeling
UR - http://www.scopus.com/inward/record.url?scp=85009064358&partnerID=8YFLogxK
U2 - 10.1016/j.jcmg.2016.11.003
DO - 10.1016/j.jcmg.2016.11.003
M3 - Review article
SN - 1936-878X
VL - 10
SP - 65
EP - 77
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
IS - 1
ER -