Linear dichroism for the detection of single base pair mutations

David J. Halsall; Alison Rodger; Timothy R. Dafforn

doi:10.1039/b107830p

Linear dichroism for the detection of single base pair mutations

David J. Halsall, Alison Rodger^*, Timothy R. Dafforn

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Flow linear dichroism is shown to be able to detect single base mismatches in a polymerase chain reaction (PCR) amplimers from exon 10 of the human β-glucocerebrosidase gene (associated with Gaucher disease) over a kilobase long with no post PCR manipulation.

Original language	English
Pages (from-to)	2410-2411
Number of pages	2
Journal	Chemical Communications
Volume	1
Issue number	23
DOIs	https://doi.org/10.1039/b107830p
Publication status	Published - 2001
Externally published	Yes

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10.1039/b107830p

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title = "Linear dichroism for the detection of single base pair mutations",

abstract = "Flow linear dichroism is shown to be able to detect single base mismatches in a polymerase chain reaction (PCR) amplimers from exon 10 of the human β-glucocerebrosidase gene (associated with Gaucher disease) over a kilobase long with no post PCR manipulation.",

author = "Halsall, \{David J.\} and Alison Rodger and Dafforn, \{Timothy R.\}",

year = "2001",

doi = "10.1039/b107830p",

language = "English",

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pages = "2410--2411",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Linear dichroism for the detection of single base pair mutations

AU - Halsall, David J.

AU - Rodger, Alison

AU - Dafforn, Timothy R.

PY - 2001

Y1 - 2001

N2 - Flow linear dichroism is shown to be able to detect single base mismatches in a polymerase chain reaction (PCR) amplimers from exon 10 of the human β-glucocerebrosidase gene (associated with Gaucher disease) over a kilobase long with no post PCR manipulation.

AB - Flow linear dichroism is shown to be able to detect single base mismatches in a polymerase chain reaction (PCR) amplimers from exon 10 of the human β-glucocerebrosidase gene (associated with Gaucher disease) over a kilobase long with no post PCR manipulation.

UR - https://www.scopus.com/pages/publications/0035824362

U2 - 10.1039/b107830p

DO - 10.1039/b107830p

M3 - Article

C2 - 12239990

AN - SCOPUS:0035824362

SN - 1359-7345

VL - 1

SP - 2410

EP - 2411

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Linear dichroism for the detection of single base pair mutations

Abstract

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