Lipotoxicity, β cell dysfunction, and gestational diabetes

Christopher J. Nolan

doi:10.1016/j.cmet.2014.03.020

Lipotoxicity, β cell dysfunction, and gestational diabetes

Christopher J. Nolan^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

19 Citations (Scopus)

Abstract

Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.

Original language	English
Pages (from-to)	553-554
Number of pages	2
Journal	Cell Metabolism
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2014.03.020
Publication status	Published - 1 Apr 2014

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title = "Lipotoxicity, β cell dysfunction, and gestational diabetes",

abstract = "Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.",

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AB - Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.

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DO - 10.1016/j.cmet.2014.03.020

M3 - Short survey

SN - 1550-4131

VL - 19

SP - 553

EP - 554

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Lipotoxicity, β cell dysfunction, and gestational diabetes

Abstract

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