Local Efficacy of Glutamate Uptake Decreases with Synapse Size

Michel K. Herde; Kirsten Bohmbach; Cátia Domingos; Natascha Vana; Joanna A. Komorowska-Müller; Stefan Passlick; Inna Schwarz; Colin J. Jackson; Dirk Dietrich; Martin K. Schwarz; Christian Henneberger

doi:10.1016/j.celrep.2020.108182

Local Efficacy of Glutamate Uptake Decreases with Synapse Size

Michel K. Herde
, Kirsten Bohmbach
, Cátia Domingos
, Natascha Vana
, Joanna A. Komorowska-Müller
, Stefan Passlick
, Inna Schwarz
, Colin J. Jackson
, Dirk Dietrich
, Martin K. Schwarz
, Christian Henneberger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Herde et al. demonstrate a dependence of the local efficacy of glutamate uptake at glutamatergic synapses on spine size. As predicted by the relative astrocytic coverage of spines, extracellular glutamate transients and Ca²⁺ entry through glutamate receptors are less strongly controlled by glutamate uptake at large than at small spines.

Original language	English
Article number	108182
Journal	Cell Reports
Volume	32
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2020.108182
Publication status	Published - 22 Sept 2020

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10.1016/j.celrep.2020.108182

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@article{edb04890cf0b471a94961644ad27a8f7,

title = "Local Efficacy of Glutamate Uptake Decreases with Synapse Size",

abstract = "Herde et al. demonstrate a dependence of the local efficacy of glutamate uptake at glutamatergic synapses on spine size. As predicted by the relative astrocytic coverage of spines, extracellular glutamate transients and Ca2+ entry through glutamate receptors are less strongly controlled by glutamate uptake at large than at small spines.",

keywords = "astrocyte morphology, astrocytes, expansion microscopy, glutamate uptake, hippocampus, multiphoton imaging, spine morphology",

author = "Herde, \{Michel K.\} and Kirsten Bohmbach and C{\'a}tia Domingos and Natascha Vana and Komorowska-M{\"u}ller, \{Joanna A.\} and Stefan Passlick and Inna Schwarz and Jackson, \{Colin J.\} and Dirk Dietrich and Schwarz, \{Martin K.\} and Christian Henneberger",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = sep,

day = "22",

doi = "10.1016/j.celrep.2020.108182",

language = "English",

volume = "32",

journal = "Cell Reports",

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TY - JOUR

T1 - Local Efficacy of Glutamate Uptake Decreases with Synapse Size

AU - Herde, Michel K.

AU - Bohmbach, Kirsten

AU - Domingos, Cátia

AU - Vana, Natascha

AU - Komorowska-Müller, Joanna A.

AU - Passlick, Stefan

AU - Schwarz, Inna

AU - Jackson, Colin J.

AU - Dietrich, Dirk

AU - Schwarz, Martin K.

AU - Henneberger, Christian

PY - 2020/9/22

Y1 - 2020/9/22

N2 - Herde et al. demonstrate a dependence of the local efficacy of glutamate uptake at glutamatergic synapses on spine size. As predicted by the relative astrocytic coverage of spines, extracellular glutamate transients and Ca2+ entry through glutamate receptors are less strongly controlled by glutamate uptake at large than at small spines.

AB - Herde et al. demonstrate a dependence of the local efficacy of glutamate uptake at glutamatergic synapses on spine size. As predicted by the relative astrocytic coverage of spines, extracellular glutamate transients and Ca2+ entry through glutamate receptors are less strongly controlled by glutamate uptake at large than at small spines.

KW - astrocyte morphology

KW - astrocytes

KW - expansion microscopy

KW - glutamate uptake

KW - hippocampus

KW - multiphoton imaging

KW - spine morphology

UR - https://www.scopus.com/pages/publications/85091349118

U2 - 10.1016/j.celrep.2020.108182

DO - 10.1016/j.celrep.2020.108182

M3 - Article

SN - 2211-1247

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 12

M1 - 108182

ER -

Local Efficacy of Glutamate Uptake Decreases with Synapse Size

Abstract

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