Localization of the chromatin remodelling protein, ATRX in the adult testis

Paisu Tang; Anthony Argentaro; Andrew J. Pask; Liza O'Donnell; Jennifer Marshall-Graves; Mary Familari; Vincent R. Harley

doi:10.1262/jrd.20221

Localization of the chromatin remodelling protein, ATRX in the adult testis

Paisu Tang, Anthony Argentaro, Andrew J. Pask, Liza O'Donnell, Jennifer Marshall-Graves, Mary Familari, Vincent R. Harley

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Mutations in ATRX (alpha-thalassaemia and mental retardation on the X-chromosome) can give rise to ambiguous or female genitalia in XY males, implying a role for ATRX in testicular development. Studies on ATRX have mainly focused on its crucial role in brain development and α-globin regulation; however, little is known about its function in sexual differentiation and its expression in the adult testis. Here we show that the ATRX protein is present in adult human and rat testis and is expressed in the somatic cells; Sertoli, Leydig, and peritubular myoid cells, and also in germ cells; spermatogonia and early meiotic spermatocytes. The granular pattern of ATRX staining is consistent with that observed in other cell-types and suggests a role in chromatin regulation. The findings suggest that ATRX in humans may play a role in adult spermatogenesis as well as in testicular development.

Original language	English
Pages (from-to)	317-321
Number of pages	5
Journal	Journal of Reproduction and Development
Volume	57
Issue number	3
DOIs	https://doi.org/10.1262/jrd.20221
Publication status	Published - Jun 2011

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title = "Localization of the chromatin remodelling protein, ATRX in the adult testis",

abstract = "Mutations in ATRX (alpha-thalassaemia and mental retardation on the X-chromosome) can give rise to ambiguous or female genitalia in XY males, implying a role for ATRX in testicular development. Studies on ATRX have mainly focused on its crucial role in brain development and α-globin regulation; however, little is known about its function in sexual differentiation and its expression in the adult testis. Here we show that the ATRX protein is present in adult human and rat testis and is expressed in the somatic cells; Sertoli, Leydig, and peritubular myoid cells, and also in germ cells; spermatogonia and early meiotic spermatocytes. The granular pattern of ATRX staining is consistent with that observed in other cell-types and suggests a role in chromatin regulation. The findings suggest that ATRX in humans may play a role in adult spermatogenesis as well as in testicular development.",

keywords = "ATR-X syndrome, Germ cells, Spermatogenesis, Testis development",

author = "Paisu Tang and Anthony Argentaro and Pask, {Andrew J.} and Liza O'Donnell and Jennifer Marshall-Graves and Mary Familari and Harley, {Vincent R.}",

year = "2011",

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T1 - Localization of the chromatin remodelling protein, ATRX in the adult testis

AU - Tang, Paisu

AU - Argentaro, Anthony

AU - Pask, Andrew J.

AU - O'Donnell, Liza

AU - Marshall-Graves, Jennifer

AU - Familari, Mary

AU - Harley, Vincent R.

PY - 2011/6

Y1 - 2011/6

N2 - Mutations in ATRX (alpha-thalassaemia and mental retardation on the X-chromosome) can give rise to ambiguous or female genitalia in XY males, implying a role for ATRX in testicular development. Studies on ATRX have mainly focused on its crucial role in brain development and α-globin regulation; however, little is known about its function in sexual differentiation and its expression in the adult testis. Here we show that the ATRX protein is present in adult human and rat testis and is expressed in the somatic cells; Sertoli, Leydig, and peritubular myoid cells, and also in germ cells; spermatogonia and early meiotic spermatocytes. The granular pattern of ATRX staining is consistent with that observed in other cell-types and suggests a role in chromatin regulation. The findings suggest that ATRX in humans may play a role in adult spermatogenesis as well as in testicular development.

AB - Mutations in ATRX (alpha-thalassaemia and mental retardation on the X-chromosome) can give rise to ambiguous or female genitalia in XY males, implying a role for ATRX in testicular development. Studies on ATRX have mainly focused on its crucial role in brain development and α-globin regulation; however, little is known about its function in sexual differentiation and its expression in the adult testis. Here we show that the ATRX protein is present in adult human and rat testis and is expressed in the somatic cells; Sertoli, Leydig, and peritubular myoid cells, and also in germ cells; spermatogonia and early meiotic spermatocytes. The granular pattern of ATRX staining is consistent with that observed in other cell-types and suggests a role in chromatin regulation. The findings suggest that ATRX in humans may play a role in adult spermatogenesis as well as in testicular development.

KW - ATR-X syndrome

KW - Germ cells

KW - Spermatogenesis

KW - Testis development

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DO - 10.1262/jrd.20221

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EP - 321

JO - Journal of Reproduction and Development

JF - Journal of Reproduction and Development

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ER -

Localization of the chromatin remodelling protein, ATRX in the adult testis

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