TY - JOUR
T1 - Longitudinal Changes in Lens Thickness and Lens Power Among Persistent Non-Myopic and Myopic Children
AU - Han, Xiaotong
AU - Xiong, Ruilin
AU - Jin, Ling
AU - Chen, Qianyun
AU - Wang, Decai
AU - Chen, Shida
AU - Chen, Xiang
AU - Ha, Jason
AU - Li, Yuting
AU - Qu, Yabin
AU - Lin, Rong
AU - He, Mingguang
AU - Morgan, Ian G.
AU - Zeng, Yangfa
AU - Liu, Yizhi
N1 - Publisher Copyright:
Copyright 2022 The Authors.
PY - 2022/9
Y1 - 2022/9
N2 - Purpose. To assess the longitudinal changes in crystalline lens in persistent non-myopic and myopic children. Methods. Four cohorts of children were recruited from Guangzhou, China, from first year of kindergarten (G0, n = 1129), first year of primary school (G1, n = 1324), fourth year of primary school (G4, n = 1854), and first year of junior high school (G7, n = 867) in 2018 and followed up annually for 2 years. All children received cycloplegic autorefraction and ocular biometry measurement. Children were classified into categories of persistent nonmyopia (PNM; spherical equivalent refraction [SER] ≥-0.5 diopter [D] at baseline and during follow-up), persistent myopia (PM; SER <-0.5 D at baseline and during followup), or newly developed myopia (NDM: SER ≥-0.5 D at baseline and <-0.5 D during follow-up). Results. The mean (SD) age was 3.69 (0.34) years for children in G0, 6.79 (0.35) years in G1, 9.52 (0.42) years in G4, and 12.56 (0.38) years in G7. A LOWESS plot showed a three-stage pattern of change in lens thickness (LT) in PNM children including a rapid decrease from 3 to 7 years of age and a slower decrease from 7 to 11 years, followed by an increase thereafter. Similar trends were observed in the PM and NDM groups, although there was less change in LT. In contrast, lens power (LP) decreased consistently in all cohorts during the follow-up. No significant changes in LT or LP were observed around myopia onset. Conclusions. The lens showed a three-stage pattern of change in LT, whereas there was continuous loss of LP in children ages 3 to 15 years.
AB - Purpose. To assess the longitudinal changes in crystalline lens in persistent non-myopic and myopic children. Methods. Four cohorts of children were recruited from Guangzhou, China, from first year of kindergarten (G0, n = 1129), first year of primary school (G1, n = 1324), fourth year of primary school (G4, n = 1854), and first year of junior high school (G7, n = 867) in 2018 and followed up annually for 2 years. All children received cycloplegic autorefraction and ocular biometry measurement. Children were classified into categories of persistent nonmyopia (PNM; spherical equivalent refraction [SER] ≥-0.5 diopter [D] at baseline and during follow-up), persistent myopia (PM; SER <-0.5 D at baseline and during followup), or newly developed myopia (NDM: SER ≥-0.5 D at baseline and <-0.5 D during follow-up). Results. The mean (SD) age was 3.69 (0.34) years for children in G0, 6.79 (0.35) years in G1, 9.52 (0.42) years in G4, and 12.56 (0.38) years in G7. A LOWESS plot showed a three-stage pattern of change in lens thickness (LT) in PNM children including a rapid decrease from 3 to 7 years of age and a slower decrease from 7 to 11 years, followed by an increase thereafter. Similar trends were observed in the PM and NDM groups, although there was less change in LT. In contrast, lens power (LP) decreased consistently in all cohorts during the follow-up. No significant changes in LT or LP were observed around myopia onset. Conclusions. The lens showed a three-stage pattern of change in LT, whereas there was continuous loss of LP in children ages 3 to 15 years.
KW - children
KW - lens power
KW - lens thickness
KW - longitudinal
KW - myopia
UR - http://www.scopus.com/inward/record.url?scp=85137864275&partnerID=8YFLogxK
U2 - 10.1167/iovs.63.10.10
DO - 10.1167/iovs.63.10.10
M3 - Article
SN - 0146-0404
VL - 63
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 10
M1 - 10
ER -