TY - JOUR
T1 - Low frequency of poultry-to-human H5N1 virus transmission, southern Cambodia, 2005
AU - Vong, Sirenda
AU - Coghlan, Benjamin
AU - Mardy, Sek
AU - Holl, Davun
AU - Seng, Heng
AU - Ly, Sovann
AU - Miller, Megge J.
AU - Buchy, Philippe
AU - Froehlich, Yves
AU - Dufourcq, Jean Baptiste
AU - Uyeki, Timothy M.
AU - Lim, Wilina
AU - Sok, Touch
PY - 2006/10
Y1 - 2006/10
N2 - To understand transmission of avian influenza A (H5N1) virus, we conducted a retrospective survey of poultry deaths and a seroepidemiologic investigation in a Cambodian village where a 28-year-old man was infected with H5N1 virus in March 2005. Poultry surveys were conducted within a 1-km radius of the patient's household. Forty-two household flocks were considered likely to have been infected from January through March 2005 because >60% of the flock died, case-fatality ratio was 100%, and both young and mature birds died within 1 to 2 days. Two sick chickens from a property adjacent to the patient's house tested positive for H5N1 on reverse transcription-PCR. Villagers were asked about poultry exposures in the past year and tested for H5N1 antibodies. Despite frequent, direct contact with poultry suspected of having H5N1 virus infection, none of 351 participants from 93 households had neutralizing antibodies to H5N1. H5N1 virus transmission from poultry to humans remains low in this setting.
AB - To understand transmission of avian influenza A (H5N1) virus, we conducted a retrospective survey of poultry deaths and a seroepidemiologic investigation in a Cambodian village where a 28-year-old man was infected with H5N1 virus in March 2005. Poultry surveys were conducted within a 1-km radius of the patient's household. Forty-two household flocks were considered likely to have been infected from January through March 2005 because >60% of the flock died, case-fatality ratio was 100%, and both young and mature birds died within 1 to 2 days. Two sick chickens from a property adjacent to the patient's house tested positive for H5N1 on reverse transcription-PCR. Villagers were asked about poultry exposures in the past year and tested for H5N1 antibodies. Despite frequent, direct contact with poultry suspected of having H5N1 virus infection, none of 351 participants from 93 households had neutralizing antibodies to H5N1. H5N1 virus transmission from poultry to humans remains low in this setting.
UR - http://www.scopus.com/inward/record.url?scp=33749985522&partnerID=8YFLogxK
U2 - 10.3201/eid1210.060424
DO - 10.3201/eid1210.060424
M3 - Review article
SN - 1080-6040
VL - 12
SP - 1542
EP - 1547
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 10
ER -