Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role

M. C. Wallis; M. L. Delbridge; A. J. Pask; A. E. Alsop; F. Grützner; P. C.M. O'Brien; W. Rens; M. A. Ferguson-Smith; J. A.M. Graves

doi:10.1159/000098192

Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role

M. C. Wallis^*, M. L. Delbridge, A. J. Pask, A. E. Alsop, F. Grützner, P. C.M. O'Brien, W. Rens, M. A. Ferguson-Smith, J. A.M. Graves

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.

Original language	English
Pages (from-to)	232-234
Number of pages	3
Journal	Cytogenetic and Genome Research
Volume	116
Issue number	3
DOIs	https://doi.org/10.1159/000098192
Publication status	Published - Feb 2007

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title = "Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role",

abstract = "In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.",

author = "Wallis, {M. C.} and Delbridge, {M. L.} and Pask, {A. J.} and Alsop, {A. E.} and F. Gr{\"u}tzner and O'Brien, {P. C.M.} and W. Rens and Ferguson-Smith, {M. A.} and Graves, {J. A.M.}",

year = "2007",

month = feb,

doi = "10.1159/000098192",

language = "English",

volume = "116",

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journal = "Cytogenetic and Genome Research",

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T1 - Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role

AU - Wallis, M. C.

AU - Delbridge, M. L.

AU - Pask, A. J.

AU - Alsop, A. E.

AU - Grützner, F.

AU - O'Brien, P. C.M.

AU - Rens, W.

AU - Ferguson-Smith, M. A.

AU - Graves, J. A.M.

PY - 2007/2

Y1 - 2007/2

N2 - In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.

AB - In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.

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U2 - 10.1159/000098192

DO - 10.1159/000098192

M3 - Article

SN - 1424-8581

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JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

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ER -

Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role

Abstract

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