Maturation of function in dendritic cells for tolerance and immunity

Ben J.C. Quah, Helen C. O'Neill*

*Corresponding author for this work

    Research output: Contribution to journalShort surveypeer-review

    78 Citations (Scopus)

    Abstract

    The capacity of antigen presenting dendritic cells (DC) to function in both tolerance and immunity is now well documented. The function and characteristics of different DC subsets are reviewed here and their capacity to activate T cells under different conditions of maturation and activation is discussed. The immunogenic potential of exosomes produced by DC is also considered in light of evidence that the capacity of exosomes to activate T cells for tolerance or immunity appears to mirror that of the parent DC. A model is proposed whereby exosomes produced by immature DC can function to maintain peripheral tolerance, while exosomes produced by more mature DC can stimulate effector T cells.

    Original languageEnglish
    Pages (from-to)643-654
    Number of pages12
    JournalJournal of Cellular and Molecular Medicine
    Volume9
    Issue number3
    DOIs
    Publication statusPublished - 2005

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