Metal-organic framework-derived porous Cu2O/Cu@C core-shell nanowires and their application in uric acid biosensor

Jinbao Luo; Jiewu Cui; Yan Wang; Dongbo Yu; Yongqiang Qin; Hongmei Zheng; Xia Shu; Hark Hoe Tan; Yong Zhang; Yucheng Wu

doi:10.1016/j.apsusc.2019.144662

Metal-organic framework-derived porous Cu₂O/Cu@C core-shell nanowires and their application in uric acid biosensor

Jinbao Luo, Jiewu Cui^*, Yan Wang, Dongbo Yu, Yongqiang Qin, Hongmei Zheng, Xia Shu, Hark Hoe Tan, Yong Zhang, Yucheng Wu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Uric acid (UA) is an important indicator for human metabolism, therefore it is of great significance to develop a sensitive and selective biosensor for monitoring UA and diagnosing relevant disorders. In this paper, porous Cu₂O/Cu@C core-shell nanowires (NWs) are synthesized by thermal decomposition of HKUST-1 NWs. Subsequently the nanowires are used as electrode materials to fabricate UA biosensors. By controlling the conditions of calcination, we obtain composite particles consisting of cuprous oxide and copper nanoparticles which are wrapped within the nanowire shell formed by non-graphitic carbon material. These nanowires exhibit excellent electrocatalytic capability at low working potential that is beneficial for improving the anti-interference ability of UA biosensors. Furthermore, carbon and copper in the substrate accelerate electron transfer to substantially improve the sensitivity of the UA biosensors. Sensitivity of 330.5 μA·mM⁻¹·cm⁻² and a linearity range from 0.05 to 1.15 mM (R² = 0.997) at a working potential of −0.5 V vs SCE are achieved. We also demonstrate the practicality of our biosensors for clinical applications by measuring the concentration of UA in diluted human urine.

Original language	English
Article number	144662
Journal	Applied Surface Science
Volume	506
DOIs	https://doi.org/10.1016/j.apsusc.2019.144662
Publication status	Published - 15 Mar 2020

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@article{a9296984309d42a3b563bbfebbe9e40b,

title = "Metal-organic framework-derived porous Cu2O/Cu@C core-shell nanowires and their application in uric acid biosensor",

abstract = "Uric acid (UA) is an important indicator for human metabolism, therefore it is of great significance to develop a sensitive and selective biosensor for monitoring UA and diagnosing relevant disorders. In this paper, porous Cu2O/Cu@C core-shell nanowires (NWs) are synthesized by thermal decomposition of HKUST-1 NWs. Subsequently the nanowires are used as electrode materials to fabricate UA biosensors. By controlling the conditions of calcination, we obtain composite particles consisting of cuprous oxide and copper nanoparticles which are wrapped within the nanowire shell formed by non-graphitic carbon material. These nanowires exhibit excellent electrocatalytic capability at low working potential that is beneficial for improving the anti-interference ability of UA biosensors. Furthermore, carbon and copper in the substrate accelerate electron transfer to substantially improve the sensitivity of the UA biosensors. Sensitivity of 330.5 μA·mM−1·cm−2 and a linearity range from 0.05 to 1.15 mM (R2 = 0.997) at a working potential of −0.5 V vs SCE are achieved. We also demonstrate the practicality of our biosensors for clinical applications by measuring the concentration of UA in diluted human urine.",

keywords = "Anti-interference ability, Core-shell structure, CuO/Cu@C composites, Metal-organic framework, Uric acid biosensor",

author = "Jinbao Luo and Jiewu Cui and Yan Wang and Dongbo Yu and Yongqiang Qin and Hongmei Zheng and Xia Shu and Tan, \{Hark Hoe\} and Yong Zhang and Yucheng Wu",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2020",

month = mar,

day = "15",

doi = "10.1016/j.apsusc.2019.144662",

language = "English",

volume = "506",

journal = "Applied Surface Science",

issn = "0169-4332",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Metal-organic framework-derived porous Cu2O/Cu@C core-shell nanowires and their application in uric acid biosensor

AU - Luo, Jinbao

AU - Cui, Jiewu

AU - Wang, Yan

AU - Yu, Dongbo

AU - Qin, Yongqiang

AU - Zheng, Hongmei

AU - Shu, Xia

AU - Tan, Hark Hoe

AU - Zhang, Yong

AU - Wu, Yucheng

PY - 2020/3/15

Y1 - 2020/3/15

N2 - Uric acid (UA) is an important indicator for human metabolism, therefore it is of great significance to develop a sensitive and selective biosensor for monitoring UA and diagnosing relevant disorders. In this paper, porous Cu2O/Cu@C core-shell nanowires (NWs) are synthesized by thermal decomposition of HKUST-1 NWs. Subsequently the nanowires are used as electrode materials to fabricate UA biosensors. By controlling the conditions of calcination, we obtain composite particles consisting of cuprous oxide and copper nanoparticles which are wrapped within the nanowire shell formed by non-graphitic carbon material. These nanowires exhibit excellent electrocatalytic capability at low working potential that is beneficial for improving the anti-interference ability of UA biosensors. Furthermore, carbon and copper in the substrate accelerate electron transfer to substantially improve the sensitivity of the UA biosensors. Sensitivity of 330.5 μA·mM−1·cm−2 and a linearity range from 0.05 to 1.15 mM (R2 = 0.997) at a working potential of −0.5 V vs SCE are achieved. We also demonstrate the practicality of our biosensors for clinical applications by measuring the concentration of UA in diluted human urine.

AB - Uric acid (UA) is an important indicator for human metabolism, therefore it is of great significance to develop a sensitive and selective biosensor for monitoring UA and diagnosing relevant disorders. In this paper, porous Cu2O/Cu@C core-shell nanowires (NWs) are synthesized by thermal decomposition of HKUST-1 NWs. Subsequently the nanowires are used as electrode materials to fabricate UA biosensors. By controlling the conditions of calcination, we obtain composite particles consisting of cuprous oxide and copper nanoparticles which are wrapped within the nanowire shell formed by non-graphitic carbon material. These nanowires exhibit excellent electrocatalytic capability at low working potential that is beneficial for improving the anti-interference ability of UA biosensors. Furthermore, carbon and copper in the substrate accelerate electron transfer to substantially improve the sensitivity of the UA biosensors. Sensitivity of 330.5 μA·mM−1·cm−2 and a linearity range from 0.05 to 1.15 mM (R2 = 0.997) at a working potential of −0.5 V vs SCE are achieved. We also demonstrate the practicality of our biosensors for clinical applications by measuring the concentration of UA in diluted human urine.

KW - Anti-interference ability

KW - Core-shell structure

KW - CuO/Cu@C composites

KW - Metal-organic framework

KW - Uric acid biosensor

UR - https://www.scopus.com/pages/publications/85079013856

U2 - 10.1016/j.apsusc.2019.144662

DO - 10.1016/j.apsusc.2019.144662

M3 - Article

SN - 0169-4332

VL - 506

JO - Applied Surface Science

JF - Applied Surface Science

M1 - 144662

ER -

Metal-organic framework-derived porous Cu₂O/Cu@C core-shell nanowires and their application in uric acid biosensor

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