Metal Oxide Nanoparticles for Cellular Response, Anti-Cancer Drugs Loading and Adsorption Kinetics

Hydrophilic anticancer drugs doxorubicin (DOX) hydrochloride, daunorubicin (DNR) and cisplatin (CPN) are the very effective anticancer agent for leukemia chemotherapy. Development of new drug delivery carriers having high loading capacity and efficiency with rapid drug loading rate to expurgate the side effects of hydrophilic anticancer drugs. Manganese oxide (Mn3O4) nanomaterial was prepared by thermal decomposition of oxalate precursor synthesized using the soft chemical method. These synthesized specimens were applied to various rat organs (liver, kidney, and brain) for subchronic toxification. Histo-investigations showed prominent pathological changes within the kidney in comparison with liver and brain. Furthermore, Mn3O4 were examined as adsorbent material for anti-cancer drugs DOX, DNR and CPN from aqueous solution. A variety of techniques X-ray diffraction (XRD), differential scanning calorimeter (DSC), thermal thermogravimetric analysis (TGA), field emission scanning electron microscope (FE-SEM), energy dispersive X-rays (EDX) and ultravioletvisible (UV-Vis) spectrophotometry were employed to characterize the samples. Light microscopy was used to check inflammatory effects within the body. The adsorption properties of anticancer drugs on Mn3O4 were studied as a function of contact time; adsorbent dosage results DOX, DNR and CPN have a maximum loading efficiency of 800, 500 and 350 mg/g respectively. Kinetics study was conducted to investigate the phenomenon and mechanism of adsorption of drugs onto Mn3O4.