Metalloproteolytic receptor shedding…platelets “acting their age”

Robert K. Andrews*, Elizabeth E. Gardiner

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    14 Citations (Scopus)

    Abstract

    Whilst significant effort has been focused on development of tools and approaches to clinically modulate activation processes that consume platelets, the platelet receptors that initiate activation processes remain untargeted. The modulation of receptor levels is also linked to underlying platelet aging processes which influence normal platelet lifespan and also the functionality and survival of stored platelets that are used in transfusion. In this review, we will focus on platelet adhesion receptors initiating thrombus formation, and discuss how regulation of levels of these receptors impact platelet function and platelet survival.

    Original languageEnglish
    Pages (from-to)512-518
    Number of pages7
    JournalPlatelets
    Volume27
    Issue number6
    DOIs
    Publication statusPublished - 17 Aug 2016

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