METTL3 Gains R/W Access to the Epitranscriptome

Ulrike Schumann; Andrew Shafik; Thomas Preiss

doi:10.1016/j.molcel.2016.04.024

METTL3 Gains R/W Access to the Epitranscriptome

Ulrike Schumann, Andrew Shafik, Thomas Preiss^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

45 Citations (Scopus)

Abstract

Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.

Original language	English
Pages (from-to)	323-324
Number of pages	2
Journal	Molecular Cell
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2016.04.024
Publication status	Published - 5 May 2016

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10.1016/j.molcel.2016.04.024

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AU - Schumann, Ulrike

AU - Shafik, Andrew

AU - Preiss, Thomas

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AB - Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.

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JO - Molecular Cell

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METTL3 Gains R/W Access to the Epitranscriptome

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