METTL3 Gains R/W Access to the Epitranscriptome

Ulrike Schumann; Andrew Shafik; Thomas Preiss

doi:10.1016/j.molcel.2016.04.024

METTL3 Gains R/W Access to the Epitranscriptome

Ulrike Schumann
, Andrew Shafik
, Thomas Preiss^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

51 Citations (Scopus)

Abstract

Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.

Original language	English
Pages (from-to)	323-324
Number of pages	2
Journal	Molecular Cell
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2016.04.024
Publication status	Published - 5 May 2016

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10.1016/j.molcel.2016.04.024

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abstract = "Epitranscriptomic marks are dynamically placed on mRNA by {"}writer{"} or {"}eraser{"} enzymes, while {"}readers{"} modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.",

author = "Ulrike Schumann and Andrew Shafik and Thomas Preiss",

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AU - Schumann, Ulrike

AU - Shafik, Andrew

AU - Preiss, Thomas

PY - 2016/5/5

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N2 - Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.

AB - Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.

UR - https://www.scopus.com/pages/publications/84966526470

U2 - 10.1016/j.molcel.2016.04.024

DO - 10.1016/j.molcel.2016.04.024

M3 - Short survey

SN - 1097-2765

VL - 62

SP - 323

EP - 324

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

METTL3 Gains R/W Access to the Epitranscriptome

Abstract

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