Mimicking biological ion channels using boron nitride nanotubes

Tamsyn A. Hilder; Dan Gordon; Shin Ho Chung

doi:10.1109/ICONN.2010.6045155

Mimicking biological ion channels using boron nitride nanotubes

Tamsyn A. Hilder^*, Dan Gordon, Shin Ho Chung

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Biological ion channels act to control a wide variety of cell functions by regulating the movement of charged ions across the cell membrane. The ability to mimic these ion channels would facilitate the development of unique biosensors, filtration devices and antibiotics. We demonstrate, using molecular and stochastic dynamics, that boron nitride nanotubes with various radii embedded in a silicon nitride membrane have the ability to mimic some of the important functions of various biological ion channels. In particular, we examine the free energy profile, and the current-voltage-concentration profiles for various ions. We find that nanotubes with a radius of 3.45, 4.83 and 5.52 are selectively permeable to water molecules, positive ions (cations) and negative ions (anions), respectively.

Original language	English
Title of host publication	ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology
Pages	368-371
Number of pages	4
DOIs	https://doi.org/10.1109/ICONN.2010.6045155
Publication status	Published - 2010
Event	2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010 - Sydney, NSW, Australia Duration: 22 Feb 2010 → 26 Feb 2010

Publication series

Name	ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

Conference

Conference	2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010
Country/Territory	Australia
City	Sydney, NSW
Period	22/02/10 → 26/02/10

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10.1109/ICONN.2010.6045155

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Hilder, T. A., Gordon, D., & Chung, S. H. (2010). Mimicking biological ion channels using boron nitride nanotubes. In ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology (pp. 368-371). Article 6045155 (ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology). https://doi.org/10.1109/ICONN.2010.6045155

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title = "Mimicking biological ion channels using boron nitride nanotubes",

abstract = "Biological ion channels act to control a wide variety of cell functions by regulating the movement of charged ions across the cell membrane. The ability to mimic these ion channels would facilitate the development of unique biosensors, filtration devices and antibiotics. We demonstrate, using molecular and stochastic dynamics, that boron nitride nanotubes with various radii embedded in a silicon nitride membrane have the ability to mimic some of the important functions of various biological ion channels. In particular, we examine the free energy profile, and the current-voltage-concentration profiles for various ions. We find that nanotubes with a radius of 3.45, 4.83 and 5.52 are selectively permeable to water molecules, positive ions (cations) and negative ions (anions), respectively.",

keywords = "Boron nitride nanotubes, Molecular dynamics, Stochastic dynamics, Synthetic ion channels",

author = "Hilder, {Tamsyn A.} and Dan Gordon and Chung, {Shin Ho}",

year = "2010",

doi = "10.1109/ICONN.2010.6045155",

language = "English",

isbn = "9781424452620",

series = "ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology",

pages = "368--371",

booktitle = "ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology",

note = "2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010 ; Conference date: 22-02-2010 Through 26-02-2010",

}

Hilder, TA, Gordon, D & Chung, SH 2010, Mimicking biological ion channels using boron nitride nanotubes. in ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology., 6045155, ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology, pp. 368-371, 2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010, Sydney, NSW, Australia, 22/02/10. https://doi.org/10.1109/ICONN.2010.6045155

Mimicking biological ion channels using boron nitride nanotubes. / Hilder, Tamsyn A.; Gordon, Dan; Chung, Shin Ho.
ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology. 2010. p. 368-371 6045155 (ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Mimicking biological ion channels using boron nitride nanotubes

AU - Hilder, Tamsyn A.

AU - Gordon, Dan

AU - Chung, Shin Ho

PY - 2010

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N2 - Biological ion channels act to control a wide variety of cell functions by regulating the movement of charged ions across the cell membrane. The ability to mimic these ion channels would facilitate the development of unique biosensors, filtration devices and antibiotics. We demonstrate, using molecular and stochastic dynamics, that boron nitride nanotubes with various radii embedded in a silicon nitride membrane have the ability to mimic some of the important functions of various biological ion channels. In particular, we examine the free energy profile, and the current-voltage-concentration profiles for various ions. We find that nanotubes with a radius of 3.45, 4.83 and 5.52 are selectively permeable to water molecules, positive ions (cations) and negative ions (anions), respectively.

AB - Biological ion channels act to control a wide variety of cell functions by regulating the movement of charged ions across the cell membrane. The ability to mimic these ion channels would facilitate the development of unique biosensors, filtration devices and antibiotics. We demonstrate, using molecular and stochastic dynamics, that boron nitride nanotubes with various radii embedded in a silicon nitride membrane have the ability to mimic some of the important functions of various biological ion channels. In particular, we examine the free energy profile, and the current-voltage-concentration profiles for various ions. We find that nanotubes with a radius of 3.45, 4.83 and 5.52 are selectively permeable to water molecules, positive ions (cations) and negative ions (anions), respectively.

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KW - Molecular dynamics

KW - Stochastic dynamics

KW - Synthetic ion channels

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SN - 9781424452620

T3 - ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

SP - 368

EP - 371

BT - ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

T2 - 2010 3rd International Conference on Nanoscience and Nanotechnology, ICONN 2010

Y2 - 22 February 2010 through 26 February 2010

ER -

Mimicking biological ion channels using boron nitride nanotubes

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