miRNA Effects on mRNA closed-loop formation during translation initiation.

Traude H. Beilharz; David T. Humphreys; Thomas Preiss

doi:10.1007/978-3-642-03103-8_7

miRNA Effects on mRNA closed-loop formation during translation initiation.

Traude H. Beilharz^*, David T. Humphreys, Thomas Preiss

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

A flurry of recent studies, carried out primarily in transfected cells or in vitro translation systems, have attempted to reveal the molecular means by which animal microRNAs (miRNAs) attenuate mRNA translation. Despite these intense efforts it has not yet been possible to derive a consensus model for such a mechanism. Here we summarise our own experimental contributions to this topic, which led us to propose that miRNAs control early translation initiation by affecting eukaryotic initiation factor 4E/cap structure and poly(A) tail function, and place them in a current context of this rapidly moving and challenging field.

Original language	English
Pages (from-to)	99-112
Number of pages	14
Journal	Progress in molecular and subcellular biology
Volume	50
DOIs	https://doi.org/10.1007/978-3-642-03103-8_7
Publication status	Published - 2010

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AU - Humphreys, David T.

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AB - A flurry of recent studies, carried out primarily in transfected cells or in vitro translation systems, have attempted to reveal the molecular means by which animal microRNAs (miRNAs) attenuate mRNA translation. Despite these intense efforts it has not yet been possible to derive a consensus model for such a mechanism. Here we summarise our own experimental contributions to this topic, which led us to propose that miRNAs control early translation initiation by affecting eukaryotic initiation factor 4E/cap structure and poly(A) tail function, and place them in a current context of this rapidly moving and challenging field.

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JO - Progress in molecular and subcellular biology

JF - Progress in molecular and subcellular biology

ER -

miRNA Effects on mRNA closed-loop formation during translation initiation.

Abstract

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