Molecular and cellular mechanisms in the viral exacerbation of asthma

Sharyn Tauro; Yung Chang Su; Sandra Thomas; Jürgen Schwarze; Klaus I. Matthaei; Dijana Townsend; Ljubov Simson; Ralph A. Tripp; Suresh Mahalingam

doi:10.1016/j.micinf.2008.07.037

Molecular and cellular mechanisms in the viral exacerbation of asthma

Sharyn Tauro, Yung Chang Su, Sandra Thomas, Jürgen Schwarze, Klaus I. Matthaei, Dijana Townsend, Ljubov Simson, Ralph A. Tripp, Suresh Mahalingam^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The aetiology of asthma associated with viral infection is complex. The dynamics that contribute to disease pathogenesis are multifactorial and involve overlapping molecular and cellular mechanisms, particularly the immune response to respiratory virus infection or allergen sensitization. This review summarizes the evidence associated with factors that may contribute to the development or exacerbation of asthma including age, host factors, genetic polymorphisms, altered immune responses, and aspects of viral antigen expression. This review also provides an important perspective of key events linked to the development of asthmatic disease and related pulmonary inflammation from human and animal studies, and discusses their relationship as targets for disease intervention strategies.

Original language	English
Pages (from-to)	1014-1023
Number of pages	10
Journal	Microbes and Infection
Volume	10
Issue number	9
DOIs	https://doi.org/10.1016/j.micinf.2008.07.037
Publication status	Published - Jul 2008

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10.1016/j.micinf.2008.07.037

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title = "Molecular and cellular mechanisms in the viral exacerbation of asthma",

abstract = "The aetiology of asthma associated with viral infection is complex. The dynamics that contribute to disease pathogenesis are multifactorial and involve overlapping molecular and cellular mechanisms, particularly the immune response to respiratory virus infection or allergen sensitization. This review summarizes the evidence associated with factors that may contribute to the development or exacerbation of asthma including age, host factors, genetic polymorphisms, altered immune responses, and aspects of viral antigen expression. This review also provides an important perspective of key events linked to the development of asthmatic disease and related pulmonary inflammation from human and animal studies, and discusses their relationship as targets for disease intervention strategies.",

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AU - Tauro, Sharyn

AU - Su, Yung Chang

AU - Thomas, Sandra

AU - Schwarze, Jürgen

AU - Matthaei, Klaus I.

AU - Townsend, Dijana

AU - Simson, Ljubov

AU - Tripp, Ralph A.

AU - Mahalingam, Suresh

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AB - The aetiology of asthma associated with viral infection is complex. The dynamics that contribute to disease pathogenesis are multifactorial and involve overlapping molecular and cellular mechanisms, particularly the immune response to respiratory virus infection or allergen sensitization. This review summarizes the evidence associated with factors that may contribute to the development or exacerbation of asthma including age, host factors, genetic polymorphisms, altered immune responses, and aspects of viral antigen expression. This review also provides an important perspective of key events linked to the development of asthmatic disease and related pulmonary inflammation from human and animal studies, and discusses their relationship as targets for disease intervention strategies.

KW - Asthma

KW - Cellular mechanism

KW - Molecular mechanism

KW - Pulmonary inflammation

KW - Viral aetiology

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VL - 10

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JO - Microbes and Infection

JF - Microbes and Infection

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ER -

Molecular and cellular mechanisms in the viral exacerbation of asthma

Abstract

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