Molecular mechanisms of inflammasome signaling

Anukriti Mathur, Jenni A. Hayward, Si Ming Man*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    150 Citations (Scopus)

    Abstract

    The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage of pro-IL-1β and -IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide-binding oligomerization domain-like receptors (NLRs), absent in melanoma 2 (AIM2)-like receptors (ALRs), or tripartite motif (TRIM) family receptors trigger the assembly of an inflammasome in response to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs). Recent studies have revealed a multitude of host components and signals that are essential for controlling canonical and noncanonical inflammasome activation and pyroptosis. These include pore-forming gasdermin proteins, the never in mitosis A-related kinase 7 (NEK7), IFN-inducible proteins (IFIs), reactive oxygen species (ROS), autophagy, potassium efflux, mitochondrial perturbations, and microbial metabolites. Here, we provide a comprehensive overview of the molecular and signaling mechanisms that provide stringent regulation over the activation and effector functions of the inflammasome.

    Original languageEnglish
    Pages (from-to)233-257
    Number of pages25
    JournalJournal of Leukocyte Biology
    Volume103
    Issue number2
    DOIs
    Publication statusPublished - Feb 2018

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