Motoric cognitive risk syndrome Multicountry prevalence and dementia risk

Joe Verghese; Cedric Annweiler; Emmeline Ayers; Nir Barzilai; Olivier Beauchet; David A. Bennett; Stephanie A. Bridenbaugh; Aron S. Buchman; Michele L. Callisaya; Richard Camicioli; Benjamin Capistrant; Somnath Chatterji; Anne Marie De Cock; Luigi Ferrucci; Nir Giladi; Jack M. Guralnik; Jeffrey M. Hausdorff; Roee Holtzer; Ki Woong Kim; Paul Kowal; Reto W. Kressig; Jae Young Lim; Susan Lord; Kenichi Meguro; Manuel Montero-Odasso; Susan W. Muir-Hunter; Mohan L. Noone; Lynn Rochester; Velandai Srikanth; Cuiling Wang

doi:10.1212/WNL.0000000000000717

Motoric cognitive risk syndrome Multicountry prevalence and dementia risk

Joe Verghese^*, Cedric Annweiler, Emmeline Ayers, Nir Barzilai, Olivier Beauchet, David A. Bennett, Stephanie A. Bridenbaugh, Aron S. Buchman, Michele L. Callisaya, Richard Camicioli, Benjamin Capistrant, Somnath Chatterji, Anne Marie De Cock, Luigi Ferrucci, Nir Giladi, Jack M. Guralnik, Jeffrey M. Hausdorff, Roee Holtzer, Ki Woong Kim, Paul KowalReto W. Kressig, Jae Young Lim, Susan Lord, Kenichi Meguro, Manuel Montero-Odasso, Susan W. Muir-Hunter, Mohan L. Noone, Lynn Rochester, Velandai Srikanth, Cuiling Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

343 Citations (Scopus)

Abstract

Objectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.

Methods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥ 4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini- Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.

Results: At baseline, 2,808 of the 26,802 participants met MCR criteria. PooledMCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.

Conclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.

Original language	English
Pages (from-to)	718-726
Number of pages	9
Journal	Neurology
Volume	83
Issue number	8
DOIs	https://doi.org/10.1212/WNL.0000000000000717
Publication status	Published - 19 Aug 2014
Externally published	Yes

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Verghese, J., Annweiler, C., Ayers, E., Barzilai, N., Beauchet, O., Bennett, D. A., Bridenbaugh, S. A., Buchman, A. S., Callisaya, M. L., Camicioli, R., Capistrant, B., Chatterji, S., De Cock, A. M., Ferrucci, L., Giladi, N., Guralnik, J. M., Hausdorff, J. M., Holtzer, R., Kim, K. W., ... Wang, C. (2014). Motoric cognitive risk syndrome Multicountry prevalence and dementia risk. Neurology, 83(8), 718-726. https://doi.org/10.1212/WNL.0000000000000717

@article{0befe4654ae946e1b522db3fda2ae5f5,

title = "Motoric cognitive risk syndrome Multicountry prevalence and dementia risk",

abstract = "Objectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.Methods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥ 4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini- Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.Results: At baseline, 2,808 of the 26,802 participants met MCR criteria. PooledMCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.Conclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.",

author = "Joe Verghese and Cedric Annweiler and Emmeline Ayers and Nir Barzilai and Olivier Beauchet and Bennett, {David A.} and Bridenbaugh, {Stephanie A.} and Buchman, {Aron S.} and Callisaya, {Michele L.} and Richard Camicioli and Benjamin Capistrant and Somnath Chatterji and {De Cock}, {Anne Marie} and Luigi Ferrucci and Nir Giladi and Guralnik, {Jack M.} and Hausdorff, {Jeffrey M.} and Roee Holtzer and Kim, {Ki Woong} and Paul Kowal and Kressig, {Reto W.} and Lim, {Jae Young} and Susan Lord and Kenichi Meguro and Manuel Montero-Odasso and Muir-Hunter, {Susan W.} and Noone, {Mohan L.} and Lynn Rochester and Velandai Srikanth and Cuiling Wang",

note = "Publisher Copyright: {\textcopyright} 2014 American Academy of Neurology.",

year = "2014",

month = aug,

day = "19",

doi = "10.1212/WNL.0000000000000717",

language = "English",

volume = "83",

pages = "718--726",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins Ltd.",

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Verghese, J, Annweiler, C, Ayers, E, Barzilai, N, Beauchet, O, Bennett, DA, Bridenbaugh, SA, Buchman, AS, Callisaya, ML, Camicioli, R, Capistrant, B, Chatterji, S, De Cock, AM, Ferrucci, L, Giladi, N, Guralnik, JM, Hausdorff, JM, Holtzer, R, Kim, KW, Kowal, P, Kressig, RW, Lim, JY, Lord, S, Meguro, K, Montero-Odasso, M, Muir-Hunter, SW, Noone, ML, Rochester, L, Srikanth, V & Wang, C 2014, 'Motoric cognitive risk syndrome Multicountry prevalence and dementia risk', Neurology, vol. 83, no. 8, pp. 718-726. https://doi.org/10.1212/WNL.0000000000000717

TY - JOUR

T1 - Motoric cognitive risk syndrome Multicountry prevalence and dementia risk

AU - Verghese, Joe

AU - Annweiler, Cedric

AU - Ayers, Emmeline

AU - Barzilai, Nir

AU - Beauchet, Olivier

AU - Bennett, David A.

AU - Bridenbaugh, Stephanie A.

AU - Buchman, Aron S.

AU - Callisaya, Michele L.

AU - Camicioli, Richard

AU - Capistrant, Benjamin

AU - Chatterji, Somnath

AU - De Cock, Anne Marie

AU - Ferrucci, Luigi

AU - Giladi, Nir

AU - Guralnik, Jack M.

AU - Hausdorff, Jeffrey M.

AU - Holtzer, Roee

AU - Kim, Ki Woong

AU - Kowal, Paul

AU - Kressig, Reto W.

AU - Lim, Jae Young

AU - Lord, Susan

AU - Meguro, Kenichi

AU - Montero-Odasso, Manuel

AU - Muir-Hunter, Susan W.

AU - Noone, Mohan L.

AU - Rochester, Lynn

AU - Srikanth, Velandai

AU - Wang, Cuiling

PY - 2014/8/19

Y1 - 2014/8/19

N2 - Objectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.Methods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥ 4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini- Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.Results: At baseline, 2,808 of the 26,802 participants met MCR criteria. PooledMCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.Conclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.

AB - Objectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.Methods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥ 4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini- Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.Results: At baseline, 2,808 of the 26,802 participants met MCR criteria. PooledMCR prevalence was 9.7% (95% confidence interval [CI] 8.2%-11.2%). MCR prevalence was higher with older age but there were no sex differences. MCR predicted risk of developing incident cognitive impairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7-2.4); aHRs were 1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9, 95% CI 1.5-2.3). The results persisted even after excluding participants with possible cognitive impairment, accounting for early dementia, and diagnostic overlap with other predementia syndromes.Conclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive decline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety of settings.

UR - http://www.scopus.com/inward/record.url?scp=84920566632&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000000717

DO - 10.1212/WNL.0000000000000717

M3 - Article

SN - 0028-3878

VL - 83

SP - 718

EP - 726

JO - Neurology

JF - Neurology

IS - 8

ER -

Motoric cognitive risk syndrome Multicountry prevalence and dementia risk

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