Mouse strains for the ubiquitous or conditional overexpression of the Flii gene

Nicole Thomsen; Anna Chappell; Radiya G. Ali; Tamsin Jones; Damian H. Adams; Klaus I. Matthaei; Hugh D. Campbell; Allison J. Cowin; Ruth M. Arkell

doi:10.1002/dvg.20735

Mouse strains for the ubiquitous or conditional overexpression of the Flii gene

Nicole Thomsen, Anna Chappell, Radiya G. Ali, Tamsin Jones, Damian H. Adams, Klaus I. Matthaei, Hugh D. Campbell, Allison J. Cowin, Ruth M. Arkell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved wound healing whereas mice with elevated Flii expression exhibit impaired wound healing. In both mice and humans Flii expression increases with age and amelioration of FLII activity represents a possible therapeutic strategy for improved wound healing in humans. Despite analysis of Flii function in a variety of organisms we know little of the molecular mechanisms underlying Flii action. Two new murine alleles of Flii have been produced to drive constitutive or tissue-specific expression of Flii. Each strain is able to rescue the embryonic lethality associated with a Flii null allele and to impair wound healing. These strains provide valuable resources for ongoing investigation of Flii function in a variety of biological processes. genesis 49:681-688, 2011.

Original language	English
Pages (from-to)	681-688
Number of pages	8
Journal	Genesis (United States)
Volume	49
Issue number	8
DOIs	https://doi.org/10.1002/dvg.20735
Publication status	Published - Aug 2011

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title = "Mouse strains for the ubiquitous or conditional overexpression of the Flii gene",

abstract = "The gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved wound healing whereas mice with elevated Flii expression exhibit impaired wound healing. In both mice and humans Flii expression increases with age and amelioration of FLII activity represents a possible therapeutic strategy for improved wound healing in humans. Despite analysis of Flii function in a variety of organisms we know little of the molecular mechanisms underlying Flii action. Two new murine alleles of Flii have been produced to drive constitutive or tissue-specific expression of Flii. Each strain is able to rescue the embryonic lethality associated with a Flii null allele and to impair wound healing. These strains provide valuable resources for ongoing investigation of Flii function in a variety of biological processes. genesis 49:681-688, 2011.",

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AU - Chappell, Anna

AU - Ali, Radiya G.

AU - Jones, Tamsin

AU - Adams, Damian H.

AU - Matthaei, Klaus I.

AU - Campbell, Hugh D.

AU - Cowin, Allison J.

AU - Arkell, Ruth M.

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Mouse strains for the ubiquitous or conditional overexpression of the Flii gene

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