TY - JOUR
T1 - Multi-Analyte Detection Based on Integrated Internal and External Sensing Approach
AU - Haider, Firoz
AU - Mashrafi, Md
AU - Aoni, Rifat Ahmmed
AU - Haider, Rakib
AU - Hossen, Moqbull
AU - Ahmed, Tanvir
AU - Mahdiraji, Ghafour Amouzad
AU - Ahmed, Rajib
N1 - Publisher Copyright:
© 2002-2011 IEEE.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Highly sensitive, simple and multiplex detection capabilities are key criteria of point-of-care (POC) diagnosis in clinical samples. Here, a simple and highly sensitive multi-analyte detection technique is proposed by using photonic crystal fiber (PCF) based surface plasmon resonance (SPR) sensor that employs both internal and external sensing approaches. The proposed sensor can detect two different analytes simultaneously by the internal and external plasmonic micro-channels. The light propagation through the sensor is controlled by the scaled-down air-holes to excite the free electrons of the plasmonic metal layers. The light- guiding and sensing properties of the sensor is numerically analyzed by using the Finite Element Method (FEM). The proposed sensor shows the maximum wavelength sensitivities (WS) of 12,000 nm/refractive index unit (RIU), and 10,000 nm/RIU, for the internal and external sensing approaches, respectively, and corresponding resolution of 8.33× 10 ^-6 RIU and 1.0× 10-5 RIU. Moreover, the hybrid sensor is applicable to detect unknown analyte refractive index (RI) in the range of 1.33 to 1.40 which covers extensively investigating analytes such as viruses, different cancer cells, glucose, proteins and DNA/RNA. Due to high sensing performance with multi-analyte detection capability, the proposed sensor can play a significant role to detect bio targets at the POC platform.
AB - Highly sensitive, simple and multiplex detection capabilities are key criteria of point-of-care (POC) diagnosis in clinical samples. Here, a simple and highly sensitive multi-analyte detection technique is proposed by using photonic crystal fiber (PCF) based surface plasmon resonance (SPR) sensor that employs both internal and external sensing approaches. The proposed sensor can detect two different analytes simultaneously by the internal and external plasmonic micro-channels. The light propagation through the sensor is controlled by the scaled-down air-holes to excite the free electrons of the plasmonic metal layers. The light- guiding and sensing properties of the sensor is numerically analyzed by using the Finite Element Method (FEM). The proposed sensor shows the maximum wavelength sensitivities (WS) of 12,000 nm/refractive index unit (RIU), and 10,000 nm/RIU, for the internal and external sensing approaches, respectively, and corresponding resolution of 8.33× 10 ^-6 RIU and 1.0× 10-5 RIU. Moreover, the hybrid sensor is applicable to detect unknown analyte refractive index (RI) in the range of 1.33 to 1.40 which covers extensively investigating analytes such as viruses, different cancer cells, glucose, proteins and DNA/RNA. Due to high sensing performance with multi-analyte detection capability, the proposed sensor can play a significant role to detect bio targets at the POC platform.
KW - Photonic crystal fiber
KW - optical fiber sensors and finite element method
KW - surface plasmon resonance
UR - http://www.scopus.com/inward/record.url?scp=85117488101&partnerID=8YFLogxK
U2 - 10.1109/TNB.2021.3108834
DO - 10.1109/TNB.2021.3108834
M3 - Article
SN - 1536-1241
VL - 21
SP - 29
EP - 36
JO - IEEE Transactions on Nanobioscience
JF - IEEE Transactions on Nanobioscience
IS - 1
ER -