Abstract
The ketone (±)-5, which embodies the bicyclic core associated with the title tRNA synthetase inhibitors 1 and 2, has been prepared via a three-component coupling reaction involving 2-(hydroxymethyl)cyclopent-2-enone (15), methylamine (6) and propiolamide (10); straightforward elaboration of the readily derived acetates (2)−21 and (+)−21 has provided the biologically active analogues 23 and 24, respectively, of the title compounds.
Original language | English |
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Pages (from-to) | 2210-2211 |
Number of pages | 2 |
Journal | Chemical Communications |
Volume | 1 |
Issue number | 21 |
DOIs | |
Publication status | Published - 2001 |