Multicavity Metallosupramolecular Architectures

Roan A.S. Vasdev, Dan Preston, James D. Crowley*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)


Discrete metallosupramolecular systems are often macrocyclic or cage-like architectures with an accessible internal cavity. Guest molecules can reside within these cavities and much of the interest in these systems is derived from these fascinating host–guest interactions. A range of potential applications stem from the ability of these metallosupramolecular architectures to encapsulate guests. These applications include catalysis or acting as molecular reaction flasks, the molecular scavenging of pollutants, storage of reactive species, and drug delivery. Multicavity metallosupramolecular architectures combine the ability of large hollow assemblies to bind multiple guests concurrently with the binding specificity associated with small cages. A variety of different approaches to generating separate compartments within a single metallosupramolecular assembly have emerged. These include interpenetrated cages, cages with polytopic ligands that have a long backbone, and molecules that have two or more clefts. This review examines these approaches, and highlights key contributions to the field.

Original languageEnglish
Pages (from-to)2513-2523
Number of pages11
JournalChemistry - An Asian Journal
Issue number19
Publication statusPublished - 5 Oct 2017
Externally publishedYes


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