Multifunctional Virus Manipulation with Large-Scale Arrays of All-Dielectric Resonant Nanocavities

Yuzhi Shi, Yongfeng Wu, Lip Ket Chin*, Zhenyu Li, Jingquan Liu, Mu Ku Chen, Shubo Wang, Yi Zhang, Patricia Yang Liu, Xiaohong Zhou, Hong Cai, Wanzhen Jin, Yefeng Yu, Ruozhen Yu, Wei Huang, Peng Huat Yap, Limin Xiao, Wee Ser, Thi Thanh Binh Nguyen, Yu Tsung LinPin Chieh Wu, Jiayan Liao, Fan Wang, C. T. Chan*, Yuri Kivshar*, Din Ping Tsai*, Ai Qun Liu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)


    Spatial manipulation of a precise number of viruses for host cell infection is essential for the extensive studies of virus pathogenesis and evolution. Albeit optical tweezers have been advanced to the atomic level via optical cooling, it is still challenging to efficiently trap and manipulate arbitrary number of viruses in an aqueous environment, being restricted by insufficient strength of optical forces and a lack of multifunctional spatial manipulation techniques. Here, by employing the virus hopping and flexibility of moving the laser position, multifunctional virus manipulation with a large trapping area is demonstrated, enabling single or massive (a large quantity of) virus transporting, positioning, patterning, sorting, and concentrating. The enhanced optical forces are produced by the confinement of light in engineered arrays of nanocavities by fine tuning of the interference resonances, and this approach allows trapping and moving viruses down to 40 nm in size. The work paves the way to efficient and precise manipulation of either single or massive groups of viruses, opening a wide range of novel opportunities for virus pathogenesis and inhibitor development at the single-virus level.

    Original languageEnglish
    Article number2100197
    JournalLaser and Photonics Reviews
    Issue number5
    Publication statusPublished - May 2022


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