Multistep Pathogenesis of Autoimmune Disease

Christopher C. Goodnow*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    358 Citations (Scopus)

    Abstract

    In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lymphocytes. The genes and molecular pathways underpinning these checkpoints overlap with those involved in tumor suppression. As with an inherited predisposition to cancer, inherited defects in self-tolerance genes typically precipitate autoimmune disease stochastically after a latent phase. Multiple mutations, inherited and somatic, may be needed before a self-reactive clone bypasses sequential tolerance checkpoints resulting in the emergence of autoimmune disease.

    Original languageEnglish
    Pages (from-to)25-35
    Number of pages11
    JournalCell
    Volume130
    Issue number1
    DOIs
    Publication statusPublished - 13 Jul 2007

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