Myc in brain development and cancer

Olga Zaytseva*, Nan Hee Kim, Leonie M. Quinn

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    18 Citations (Scopus)

    Abstract

    The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC’s capacity to promote programs of proliferative cell growth, MYC is frequently upregulated in cancer. Although members of the MYC family are upregulated in nervous system tumours, the mechanisms of how elevated MYC promotes stem cell-driven brain cancers is unknown. If we are to determine how increased MYC might contribute to brain cancer progression, we will require a more complete understanding of MYC’s roles during normal brain development. Here, we evaluate evidence for MYC family functions in neural stem cell fate and brain development, with a view to better understand mechanisms of MYC-driven neural malignancies.

    Original languageEnglish
    Article number7742
    Pages (from-to)1-14
    Number of pages14
    JournalInternational Journal of Molecular Sciences
    Volume21
    Issue number20
    DOIs
    Publication statusPublished - 2 Oct 2020

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