Myc in Stem Cell Behaviour: Insights from Drosophila

Leonie Quinn, Julie Secombe, Gary R. Hime

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.
    Original languageEnglish
    Pages (from-to)269-285pp
    JournalAdvances in Experimental Medicine and Biology
    Volume786
    DOIs
    Publication statusPublished - 2013

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