TY - JOUR
T1 - Myc in Stem Cell Behaviour: Insights from Drosophila
AU - Quinn, Leonie
AU - Secombe, Julie
AU - Hime, Gary R.
PY - 2013
Y1 - 2013
N2 - The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.
AB - The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.
U2 - 10.1007/978-94-007-6621-1_15
DO - 10.1007/978-94-007-6621-1_15
M3 - Article
VL - 786
SP - 269
EP - 285
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -