Myc in Stem Cell Behaviour: Insights from Drosophila

Leonie Quinn; Julie Secombe; Gary R. Hime

doi:10.1007/978-94-007-6621-1_15

Myc in Stem Cell Behaviour: Insights from Drosophila

Leonie Quinn
, Julie Secombe
, Gary R. Hime

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.

Original language	English
Pages (from-to)	269-285pp
Journal	Advances in Experimental Medicine and Biology
Volume	786
DOIs	https://doi.org/10.1007/978-94-007-6621-1_15
Publication status	Published - 2013

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title = "Myc in Stem Cell Behaviour: Insights from Drosophila",

abstract = "The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.",

author = "Leonie Quinn and Julie Secombe and Hime, \{Gary R.\}",

year = "2013",

doi = "10.1007/978-94-007-6621-1\_15",

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AU - Quinn, Leonie

AU - Secombe, Julie

AU - Hime, Gary R.

PY - 2013

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N2 - The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.

AB - The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.

U2 - 10.1007/978-94-007-6621-1_15

DO - 10.1007/978-94-007-6621-1_15

M3 - Article

VL - 786

SP - 269

EP - 285

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Myc in Stem Cell Behaviour: Insights from Drosophila

Abstract

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