N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat

Charles K. Mondo; Yi Zhang; Vinicius De Macedo Possamai; Yuchun Miao; Christopher G. Schyvens; Katja U.S. McKenzie; Lexian Hu; Zhijun Guo; Judith A. Whitworth

doi:10.1080/10641960500468219

N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat

Charles K. Mondo, Yi Zhang, Vinicius De Macedo Possamai, Yuchun Miao, Christopher G. Schyvens, Katja U.S. McKenzie, Lexian Hu, Zhijun Guo, Judith A. Whitworth^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We investigated the effect of antioxidant N-acetylcysteine (NAC) on adrenocorticotropic hormone (ACTH)-hypertension, Male Sprague-Dawley rats received NAC (10 mg/L) or water 4 days before ACTH/saline treatment for 13 days (prevention study). In a reversal study, NAC commenced on day 8 of ACTH/saline treatment and continued for 5 days. ACTH increased systolic blood pressure (SBP) in water drinking rats (111 ± 1 to 131 ± 3 mmHg, p < 0.001). In the prevention study, NAC + ACTH increased SBP (108 ± 2 to 120 ± 2 mmHg, p < 0.001) but less than ACTH alone (p′ < 0.05). In the reversal study, NAC had no significant effect (132 ± 4 to 124 ± 3 mmHg, ns). Thus, NAC partially prevented but did not reverse ACTH-induced hypertension.

Original language	English
Pages (from-to)	73-84
Number of pages	12
Journal	Clinical and Experimental Hypertension
Volume	28
Issue number	2
DOIs	https://doi.org/10.1080/10641960500468219
Publication status	Published - Feb 2006

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title = "N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat",

abstract = "We investigated the effect of antioxidant N-acetylcysteine (NAC) on adrenocorticotropic hormone (ACTH)-hypertension, Male Sprague-Dawley rats received NAC (10 mg/L) or water 4 days before ACTH/saline treatment for 13 days (prevention study). In a reversal study, NAC commenced on day 8 of ACTH/saline treatment and continued for 5 days. ACTH increased systolic blood pressure (SBP) in water drinking rats (111 ± 1 to 131 ± 3 mmHg, p < 0.001). In the prevention study, NAC + ACTH increased SBP (108 ± 2 to 120 ± 2 mmHg, p < 0.001) but less than ACTH alone (p′ < 0.05). In the reversal study, NAC had no significant effect (132 ± 4 to 124 ± 3 mmHg, ns). Thus, NAC partially prevented but did not reverse ACTH-induced hypertension.",

keywords = "Adrenocorticotropic hormone, Blood pressure, N-acetylcysteine, Rat",

author = "Mondo, {Charles K.} and Yi Zhang and {De Macedo Possamai}, Vinicius and Yuchun Miao and Schyvens, {Christopher G.} and McKenzie, {Katja U.S.} and Lexian Hu and Zhijun Guo and Whitworth, {Judith A.}",

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doi = "10.1080/10641960500468219",

language = "English",

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T1 - N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat

AU - Mondo, Charles K.

AU - Zhang, Yi

AU - De Macedo Possamai, Vinicius

AU - Miao, Yuchun

AU - Schyvens, Christopher G.

AU - McKenzie, Katja U.S.

AU - Hu, Lexian

AU - Guo, Zhijun

AU - Whitworth, Judith A.

PY - 2006/2

Y1 - 2006/2

N2 - We investigated the effect of antioxidant N-acetylcysteine (NAC) on adrenocorticotropic hormone (ACTH)-hypertension, Male Sprague-Dawley rats received NAC (10 mg/L) or water 4 days before ACTH/saline treatment for 13 days (prevention study). In a reversal study, NAC commenced on day 8 of ACTH/saline treatment and continued for 5 days. ACTH increased systolic blood pressure (SBP) in water drinking rats (111 ± 1 to 131 ± 3 mmHg, p < 0.001). In the prevention study, NAC + ACTH increased SBP (108 ± 2 to 120 ± 2 mmHg, p < 0.001) but less than ACTH alone (p′ < 0.05). In the reversal study, NAC had no significant effect (132 ± 4 to 124 ± 3 mmHg, ns). Thus, NAC partially prevented but did not reverse ACTH-induced hypertension.

AB - We investigated the effect of antioxidant N-acetylcysteine (NAC) on adrenocorticotropic hormone (ACTH)-hypertension, Male Sprague-Dawley rats received NAC (10 mg/L) or water 4 days before ACTH/saline treatment for 13 days (prevention study). In a reversal study, NAC commenced on day 8 of ACTH/saline treatment and continued for 5 days. ACTH increased systolic blood pressure (SBP) in water drinking rats (111 ± 1 to 131 ± 3 mmHg, p < 0.001). In the prevention study, NAC + ACTH increased SBP (108 ± 2 to 120 ± 2 mmHg, p < 0.001) but less than ACTH alone (p′ < 0.05). In the reversal study, NAC had no significant effect (132 ± 4 to 124 ± 3 mmHg, ns). Thus, NAC partially prevented but did not reverse ACTH-induced hypertension.

KW - Adrenocorticotropic hormone

KW - Blood pressure

KW - N-acetylcysteine

KW - Rat

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U2 - 10.1080/10641960500468219

DO - 10.1080/10641960500468219

M3 - Article

SN - 1064-1963

VL - 28

SP - 73

EP - 84

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

IS - 2

ER -

N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat

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