Nanoparticles mimicking viral surface topography for enhanced cellular delivery

Yuting Niu; Meihua Yu; Sandy B. Hartono; Jie Yang; Hongyi Xu; Hongwei Zhang; Jun Zhang; Jin Zou; Annette Dexter; Wenyi Gu; Chengzhong Yu

doi:10.1002/adma.201302737

Nanoparticles mimicking viral surface topography for enhanced cellular delivery

Yuting Niu, Meihua Yu, Sandy B. Hartono, Jie Yang, Hongyi Xu, Hongwei Zhang, Jun Zhang, Jin Zou, Annette Dexter, Wenyi Gu, Chengzhong Yu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

186 Citations (Scopus)

Abstract

Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20â€...μm).

Original language	English
Pages (from-to)	6233-6237
Number of pages	5
Journal	Advanced Materials
Volume	25
Issue number	43
DOIs	https://doi.org/10.1002/adma.201302737
Publication status	Published - 20 Nov 2013
Externally published	Yes

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title = "Nanoparticles mimicking viral surface topography for enhanced cellular delivery",

abstract = "Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20{\^a}€...μm).",

keywords = "biomimetic synthesis, drug delivery, nanoparticles, surface topography",

author = "Yuting Niu and Meihua Yu and Hartono, {Sandy B.} and Jie Yang and Hongyi Xu and Hongwei Zhang and Jun Zhang and Jin Zou and Annette Dexter and Wenyi Gu and Chengzhong Yu",

year = "2013",

month = nov,

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doi = "10.1002/adma.201302737",

language = "English",

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journal = "Advanced Materials",

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T1 - Nanoparticles mimicking viral surface topography for enhanced cellular delivery

AU - Niu, Yuting

AU - Yu, Meihua

AU - Hartono, Sandy B.

AU - Yang, Jie

AU - Xu, Hongyi

AU - Zhang, Hongwei

AU - Zhang, Jun

AU - Zou, Jin

AU - Dexter, Annette

AU - Gu, Wenyi

AU - Yu, Chengzhong

PY - 2013/11/20

Y1 - 2013/11/20

N2 - Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20â€...μm).

AB - Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20â€...μm).

KW - biomimetic synthesis

KW - drug delivery

KW - nanoparticles

KW - surface topography

UR - http://www.scopus.com/inward/record.url?scp=84888006928&partnerID=8YFLogxK

U2 - 10.1002/adma.201302737

DO - 10.1002/adma.201302737

M3 - Article

C2 - 23946251

AN - SCOPUS:84888006928

SN - 0935-9648

VL - 25

SP - 6233

EP - 6237

JO - Advanced Materials

JF - Advanced Materials

IS - 43

ER -

Nanoparticles mimicking viral surface topography for enhanced cellular delivery

Abstract

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