Nanoparticles mimicking viral surface topography for enhanced cellular delivery

Yuting Niu, Meihua Yu, Sandy B. Hartono, Jie Yang, Hongyi Xu, Hongwei Zhang, Jun Zhang, Jin Zou, Annette Dexter, Wenyi Gu, Chengzhong Yu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

172 Citations (Scopus)


Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20â€...μm).

Original languageEnglish
Pages (from-to)6233-6237
Number of pages5
JournalAdvanced Materials
Issue number43
Publication statusPublished - 20 Nov 2013
Externally publishedYes


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