TY - JOUR
T1 - Narrative Review
T2 - Clinical Implications and Assessment of Frailty in Patients With Advanced CKD
AU - Kennard, Alice L.
AU - Glasgow, Nicholas J.
AU - Rainsford, Suzanne E.
AU - Talaulikar, Girish S.
N1 - Publisher Copyright:
© 2024
PY - 2024/4
Y1 - 2024/4
N2 - Frailty is a multidimensional clinical syndrome characterized by low physical activity, reduced strength, accumulation of multiorgan deficits, decreased physiological reserve, and vulnerability to stressors. Frailty has key social, psychological, and cognitive implications. Frailty is accelerated by uremia, leading to a high prevalence of frailty in patients with advanced chronic kidney disease (CKD) and end-stage kidney disease (ESKD) as well as contributing to adverse outcomes in this patient population. Frailty assessment is not routine in patients with CKD; however, a number of validated clinical assessment tools can assist in prognostication. Frailty assessment in nephrology populations supports shared decision-making and advanced communication and should inform key medical transitions. Frailty screening and interventions in CKD or ESKD are a developing research priority with a rapidly expanding literature base.
AB - Frailty is a multidimensional clinical syndrome characterized by low physical activity, reduced strength, accumulation of multiorgan deficits, decreased physiological reserve, and vulnerability to stressors. Frailty has key social, psychological, and cognitive implications. Frailty is accelerated by uremia, leading to a high prevalence of frailty in patients with advanced chronic kidney disease (CKD) and end-stage kidney disease (ESKD) as well as contributing to adverse outcomes in this patient population. Frailty assessment is not routine in patients with CKD; however, a number of validated clinical assessment tools can assist in prognostication. Frailty assessment in nephrology populations supports shared decision-making and advanced communication and should inform key medical transitions. Frailty screening and interventions in CKD or ESKD are a developing research priority with a rapidly expanding literature base.
KW - assessment
KW - communication
KW - frailty
KW - kidney disease
KW - rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=85183844413&partnerID=8YFLogxK
U2 - 10.1016/j.ekir.2023.12.022
DO - 10.1016/j.ekir.2023.12.022
M3 - Article
SN - 2468-0249
VL - 9
SP - 791
EP - 806
JO - Kidney International Reports
JF - Kidney International Reports
IS - 4
ER -