TY - JOUR
T1 - Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy
AU - Khalilpour, Saba
AU - Behnammanesh, Ghazaleh
AU - Suede, Fouad
AU - Ezzat, Mohammed O.
AU - Muniandy, Jayadhisan
AU - Tabana, Yasser
AU - Ahamed, Mohamed B.K.
AU - Tamayol, Ali
AU - Majid, Amin Malik Shah
AU - Sangiovanni, Enrico
AU - Dell'Agli, Mario
AU - Majid, Aman Shah
N1 - Publisher Copyright:
© 2018 by the authors.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β-carotene were 6.79 ± 0.009 μg/mL, 10.94 ± 0.09 μg/mL, and 6.25 ± 0.06 μg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.
AB - Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β-carotene were 6.79 ± 0.009 μg/mL, 10.94 ± 0.09 μg/mL, and 6.25 ± 0.06 μg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.
KW - Anti-neuroinflammation
KW - Ischemic optic neuropathy
KW - Linoleic acid
KW - Neuroprotection
KW - Rhus coriaria
UR - http://www.scopus.com/inward/record.url?scp=85050315614&partnerID=8YFLogxK
U2 - 10.3390/biomedicines6020048
DO - 10.3390/biomedicines6020048
M3 - Article
SN - 2227-9059
VL - 6
JO - Biomedicines
JF - Biomedicines
IS - 2
M1 - 48
ER -